This thesis probes under what conditions quantum computing presents an advantage over classical computing.

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

In this thesis we examine certain phenomena in symplectic topology which are related to the theory of isolated singularities.

De lerarenopleiding bestaat uit een praktijk- en theoriegedeelte. Deze onderdelen zijn sterk met elkaar verbonden. Op maandag volg je onderwijs op de universiteit, de rest van de week sta je voor de klas op een middelbare school.

Op 9 juni 2021 verdedigde Bahaddin Budak succesvol zijn proefschrift en promoveerde.

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

We are living in an information era where the amount of image and video data increases exponentially.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.