The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Den Haag, multiculturele en meertalige stad bij uitstek, vormt een uitdaging voor taalkundigen. Maar hoeveel talen er worden gesproken, is niet bekend. Ingrid Tieken-Boon van Ostade probeert daar achter te komen door de sprekers op te zoeken en ze te interviewen over hun moedertaal.

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

Promotores: G.W. Canters, T.J. Aartsma

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

The specialisation Science Communication and Society (SCS) concerns science communication in a broad sense. The program focuses on the link between science and society and covers knowledge and skills in the field of science communication.

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Van oudsher werden donder en bliksem gezien als Gods strafwerktuigen. De uitvinding van de bliksemafleider door Benjamin Franklin in 1752 bracht hierin echter verandering. Welke gevolgen hadden de uitvinding en invoering van de bliksemafleider voor de manier waarop men aankeek tegen het onweer? Jan…

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Rond het jaar 1900 maakten zowel de Nederlandse letteren als de stad Den Haag ingrijpende ontwikkelingen door. De romans werden moderner, experimenteler, en vooral vrijmoediger. Deze bundel bespreekt romans van bekende Haagse auteurs als Louis Couperus en Marcellus Emants, maar ook van minder bekende,…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. D. Bouwmeester

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Lezing

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Control of infectious diseases poses continuous challenges for human health.

Promotores: S.F. Portegies Zwart, E. M. Rossi