1,513 zoekresultaten voor “chemisch weapons en ethiek” in de Publieke website
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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Role of near-surface environment in tuning electrochemical CO2 reduction reaction and H2 evolution reaction
This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…
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Inhibitors and probes targeting endo-glycosidases
The chemical synthesis of inhibitors and probes targeting endo-glycosidases.
- Elastin-like polypeptide micelles for vaccine delivery
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Design, synthesis and application of sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases
This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.
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MAGL modulators: structure-guided optimisation and characterisation
The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Patrick Overeem wint ISRF Early Career Fellowship
Hoe komen in de Nederlandse politiek compromissen tot stand? Waarom zijn sommige compromissen beter dan andere? En in hoeverre zijn kenmerken van de politici die aan de compromisvorming deelnemen bepalend voor de morele kwaliteit van een compromis? Universitair docent dr. Patrick Overeem gaat in 2016…
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PRE-Class Lectures 2018
Ook dit jaar waren de presentaties op het jaarlijkse slotevenement van de PRE-Classes van hoog niveau! Bleda Dühring, de keynote speaker, liet zien hoe een archeologische opgraving over het Assyrische rijk nog heel relevant is vandaag de dag. De Pre-Classers vertelden enthousiast over uiteenlopende…
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Studieprogramma
De studie Bio-Farmaceutische Wetenschappen richt zich specifiek op geneesmiddelenontwikkeling. Je bestudeert de (bij)werking van geneesmiddelen en kijkt naar de mechanismen van ziektes.
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GMP-faciliteit voor innovatieve geneesmiddelen (KFT-J10 / IGFL)
De GMP-faciliteit maaktde ontwikkeling en productie van Advanced Therapy Medicinal Products (ATMP's) en chemische (peptide) synthese mogelijk.
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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Biomimetic redox reactions of the Cu(II) μ-thiolate complex
Promotor: Prof.dr. E. Bouwman
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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Laboratory for Astrophysics
We simuleren interstellaire wolken met speciale plasma-expansies en chemische reacties op ijzige stofdeeltjes in ultrahoogvacuümopstellingen. Dit levert gegevens die nodig zijn om astronomische waarnemingen te interpreteren en de reactienetwerken in de ruimte te modelleren.
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Peptide Facility
Peptiden worden routinematig gesynthetiseerd in het bereik van 5-80 aminozuren, in een hoeveelheid van 1-200 µmol (kleinere en grotere hoeveelheden zijn ook mogelijk).
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Synthesis of D-alanylated wall teichoic acids from staphylococcus aureus
This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.
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Transition metal compounds with S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
- Onderzoeksoutput
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Voor wie
Het Centrum voor Juridisch Ondernemerschap en Innovatie vindt het belangrijk dat docenten, studenten en onderzoekers geïnformeerd worden over de impact van technologische ontwikkelingen in het juridische werkveld in het kader van de relevantie van het onderwijs, de aanknopingspunten voor academisch…
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AI voor mens, maatschappij en wetenschap
Verantwoorde AI voor een sterke en veerkrachtige samenleving en wetenschap.
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MOOC The Importance and Power of Music in our Society
Online cursus The Importance and Power of Music in our Society
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IOnderzoeksgroep ntelligence and Security
De onderzoeksgroep Intelligence and Security houdt zich bezig met inlichtingen en veiligheid binnen de Europese Unie. De aanpak is interdisciplinair en weerspiegelt de brede benadering van het ISGA. Inzichten uit onder meer ethiek, geschiedenis, recht, politicologie, psychologie en sociologie worden…
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Krijgsgeweld en kolonie. Opkomst en ondergang van Nederland als koloniale mogendheid 1816-2010
Dit recent verschenen boek analyseert en verklaart de opkomst en ondergang van Nederland als koloniale mogendheid vanuit militair perspectief.
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The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.
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Over de opleiding
Ontdek de MSc Political Theory: Legitimiteit en Rechtvaardigheid aan Universiteit Leiden — met focus op politieke filosofie, diepgaande theorievakken, keuzevakken, en afsluiting met scriptie of stage.
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ERC Starting Grant voor chemicus Sander van Kasteren
Kunnen suikerpatronen op cellen het immuunsysteem activeren om kanker te bestrijden? Sander van Kasteren gebruikt de beurs van de European Research Council (ERC) om te ontdekken of dit mogelijk is.
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Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
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Electrocatalytic reduction of CO2 and nitrate on immobilized metal porphyrins
M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid
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Chemical synthesis of fragments of galactosaminogalactan and pel polysaccharides
The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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The Metallophilic Interaction between Cyclometalated Complexes: Photobiological Applications
In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.
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Synthesis of cyclic peptides as bioconjugation platforms
Cyclic peptides are investigated as a platform to induce different orientations between various ligands.
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Photo-activated drug delivery systems
O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.
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Essentiality of conserved amino acid residues in β-lactamase
Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Synthesis and Characterization of Boron, Nitrogen, and Carbon-Based Two-Dimensional Materials
This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.
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Copper trispyrazolylborate complexes for ethene detection
Promotor: E. Bouwman, Co-Promotor: S. Bonnet
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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Design of homogeneous water oxidation catalysts
To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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Selective and efficient electrochemical CO2 reduction on nanostructured catalysts
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.