De onderzoeksgroep Governance of Crises bestudeert fenomenen, dynamieken en actoren die te maken hebben met crisisgovernance. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoeksgroep.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

De incubatietijd (van infectie tot de eerste symptomen) en latente periode (van infectie tot de start van besmettelijkheid) zijn cruciaal voor het informeren van controle maatregelen aan het begin van een infectieziektenuitbraak. Een voorbeeld is de duur van quarantaine voor potentieel geïnfecteerden,…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

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Bekijk, beluister, proef en kook zelf in de Smaakstudio opgezet door, onder anderen, archeologe dr. Joanita Vroom, in het kader van een nieuwe tentoonstelling in het Wereldmuseum, Rotterdam. Joanita Vroom geeft ook een serie workshops over voedsel uit het verleden.

In dit artikel onderzoeken Chiara Anfuso, Andrea Bartolucci, Cristina del Real en Sanneke Kuipers cyberdreigingen in de humanitaire hulpverlening. Ze gaan na hoe digitalisering de kwetsbaarheid vergroot en brengen de uitdagingen in kaart waarmee organisaties worden geconfronteerd bij het versterken…

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Het is een tragisch feit dat er over de hele wereld massale wreedheden zijn en nog steeds plaatsvinden. Hoewel de internationale gemeenschap deze daden veroordeelt, blijft zij vaak werkeloos toekijken. Dit raadsel roept een groot aantal empirische, juridische en normatieve vragen op over de rol van…

Promotor: Prof.dr. M.A.G.J. Orrit

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

Kunst en vrije tijd, Kunst en vrije tijd

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Bij de Onderzoeksgroep Geweld en Geweldpreventie (Violence and Violence Prevention) wordt onderzoek gedaan naar de complexiteit van hedendaags geweld, de uiteenlopende verschijningsvormen ervan en strategieën voor preventie.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

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Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

Is het mogelijk om oxytocine reacties bij gezonde personen farmacologisch te conditioneren en de neurale circuits te identificeren die aan deze conditionering ten grondslag liggen?

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame