Het fundamentele recht op ‘vrijheid van de kunsten en het wetenschappelijk onderzoek’ in de EU: een verkenning van de grenzen van de commercialisering van de academie (AFITE).

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

De Universiteit Leiden is vijf plaatsen gestegen in de ‘Academic Ranking of World Universities’ van de Universiteit van Shanghai. Wereldwijd staat Leiden nu op plaats 65.

Sinds 3 mei 2016 is de Universiteit Leiden toegelaten als Academic Member en Founding Member van het European Banking Institute (EBI).

De samenwerking beslaat tal van terreinen zoals de bestrijding van infectieziekten, klinische testen, de productie van medicijnen en e-health. Door de krachten te bundelen kunnen we patiënten nog betere en innovatieve zorg bieden, aldus de drie partners.

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap naar klinische tests tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

We leveren fenotypische read- outs voor diagnose en patiënt stratificatie voor een behandeling op basis van innovatieve metabolomics, UPE en organ-on-a-chip technologie. Met een farmacologische én biologische aanpak bieden we inzicht in ziektemechanismen en vertalen dat voor de gepersonaliseerde gen…

Kan het eiwit PRG4 helpen om de symptomen van reumatoïde artritis te voorkomen of te verlichten?

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Promotores: J. Jonkers, K.E. de Visser

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. B. van de Water

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: B. van de Water

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.