In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

During the course of drug discovery translational steps are made.

Welke relatie bestaat er tussen verschillende type PLGs en cognitieve differentiatie?

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Data theory research on the analysis on the multidimensional data

Promotor: W. Jiskoot, Co-promotor: A. Kros

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Promotie

Lezing

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

In 2025 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen ontvangen en belangrijke onderzoekssubsidies binnengehaald.

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap naar klinische tests tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

We leveren fenotypische read- outs voor diagnose en patiënt stratificatie voor een behandeling op basis van innovatieve metabolomics, UPE en organ-on-a-chip technologie. Met een farmacologische én biologische aanpak bieden we inzicht in ziektemechanismen en vertalen dat voor de gepersonaliseerde gen…

Kan het eiwit PRG4 helpen om de symptomen van reumatoïde artritis te voorkomen of te verlichten?

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Promotores: J. Jonkers, K.E. de Visser

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. B. van de Water

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: B. van de Water

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

De juiste student op de juiste plek