The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

In the first part of this thesis we study the geometry of folding patterns.

Supervisor: P.J.J. Hooykaas

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Workshop

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

This course provides an insider perspective into the work of international criminal courts and tribunals. You will learn about the investigation and prosecution of international crimes in The Hague.

In this course, you will gain a deep insight into the rules that govern armed conflict, and aim to mitigate human suffering on the battlefield. You will explore the why and how of International Humanitarian Law, followed by the different types of conflict.

Van zwarte gaten tot kunstmatige intelligentie en van medicijnonderzoek tot data science: welkom in de fascinerende wereld van de Faculteit der Wiskunde en Natuurwetenschappen. Geregeld geven onze onderzoekers, studenten en gasten publieke lezingen over hun werk. U bent van harte uitgenodigd.

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

Kunst en vrije tijd, Kunst en vrije tijd

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

In this thesis I examine how soil biotic and abiotic characteristics change and interact throughout the course of afforestation and how they subsequently impact tree performance.

In this thesis, we examine various systems through the lens of several numerical methods.

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. G.J. Kroes

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Kunst en vrije tijd, Kunst en vrije tijd

The project

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

In this thesis, classes of strongly interacting quantum field theories, have been studied.

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.