Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Technologies that help to enhance our educational environments can be found everywhere.

Op 11 mei 2016 ontving het Hazelhoff Centre for Financial Law Robert Pickel voor de elfde Hazelhoff Guest Lecture, getiteld ‘The Deadliest Sin of the Financial Crisis’.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Op 12 januari 2022 verdedigde Mirjam Franke het proefschrift 'Over de grens van de onrechtmatige daad'. Het promotieonderzoek is begeleid door prof.mr. A.G. Castermans en prof.mr. J.H. Crijns.

Hoe kunnen studenten in mbo- en hoger onderwijsinstellingen het beste worden ondersteund in hun studiekeuze en studieloopbaan met het oog op soepele in- en doorstroom in opleiding en werk?

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

Op donderdag 7 en vrijdag 8 december 2017 organiseerden het Hazelhoff Centre for Financial Law van de Leidse rechtenfaculteit en het European University Institute in Florence een PhD workshop in Leiden.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

The ministry of education (OC en W) has generously decided to subsidize the Encompass program with a grant of 1 million euro’s for the years 2012-2016.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Including modelling as part of software development appears to have various benefits.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Promotor: Prof.dr. H.J.A. Rottgering

De Sociaal-Democratische Arbeiderspartij (SDAP) was een politiek experiment. Bij haar oprichting in 1894 hadden de meeste leden geen stemrecht, de leiders geen politieke ervaring en stond de organisatievorm nog in de kinderschoenen. Wie lid werd, zette bovendien zijn geld, goede naam en baan op het…

Dit boek, samengesteld door voormalig BVD-historicus Dick Engelen en historicus Constant Hijzen, geeft een overzicht van lokaties in Nederland die in de twintigste eeuw iets te maken hebben gehad met spionage en geheime diensten uit binnen- en buitenland.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Op 11 november 2016 organiseren de afdeling Staats- en bestuursrecht, The Hague Law Labs en de Italian Association for European and Comparative Law de conferentie ‘The Dutch Constitution Beyond 200: tradition and innovation in a multilevel order’, waarbij Nederlandse onderzoekers in dialoog met internationale…

Contacts between English and Dutch speakers had a profound impact on the literary landscape and book culture of England and the Low Countries. This conference crosses conventional chronological, linguistic, geographical and disciplinary boundaries to explore the cultural history of relations between…

A series of sessions on the literary heritage of Anglo-Dutch relations (c. 1050-c. 1600) will be held at the Society for Renaissance Studies (29 June - 1 July 2021).

Call for Papers: Yearbook for Dutch Book History 33 (2026). Deadline 1 April 2025.

Promotor: Prof.dr. S. Haring

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Het Binnenhof is het centrum van de politiek in Nederland. De eeuwenoude politieke functie van dit gebouwencomplex in Den Haag en de combinatie van bestuur, regeringsleiding en volksvertegenwoordiging op één plaats maken het Binnenhof een uniek brandpunt van de geschiedenis van Nederland.

De vijand willen we liever geen gezicht geven. De vijand is bruut en gewelddadig. Dat geldt zeker voor de Spaanse militairen die namens koning Filips II de Opstand in de Nederlanden kwamen onderdrukken. Wat gebeurt er als we ze toch een gezicht geven? Raymond Fagel, universitair docent Algemene Geschiedenis,…

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.