809 zoekresultaten voor “efficient medicijnontwikkeling” in de Publieke website
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Graphene at fluidic interfaces
In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Solution in Dissolution: dynamics and fate of metal-based nanoparticles in toxicity assessment
Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…
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A macro level assessment of material circularity
A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.
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Miniaturized metabolomics methods for enabling the study of biomass- restricted samples
This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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Towards a Circular Food System: Global Resource Losses, Waste Typologies, and Valorization Pathways
Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Progressive Indexes
Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…
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Size effects in microstructured superconductors and quantum materials
We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.
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Multi-Objective Bayesian Global Optimization for Continuous Problems and Applications
A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.
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Natural Computing and Optimization
Het onderzoek in het natural computing cluster omvat theoretische fundamenten, de ontwikkeling van nieuwe algoritmen en interdisciplinaire toepassingen van natuurlijke computermethoden. De drijvende kracht achter hun onderzoek is de missie om het begrip van natuurlijke systemen als rekenmodellen te…
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When galaxy clusters collide: the impact of merger shocks on cluster gas and galaxy evolution
Promotor: Prof.dr. H.J.A. Rottgering
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Unlocking Cosmic Depth and Detail
This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.
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Woonconcept
Samen wonen in een residentiële setting voegt een extra dimensie toe aan dit leren, omdat onze studenten moeten leren samen te leven met anderen die mogelijk niet dezelfde dagelijkse routines of normen delen.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Dynamics and radiation from tidal disruption events
When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Improving targeted gene editing in Arabidopsis thaliana
Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.
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Getting personal: Advancing personalized oncology through computational analysis of membrane proteins
Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Verwijzing naar tekst tijdens het lezen van e-storyboeken op een SMARTboard ter bevordering van beginnende geletterdheid bij kleuters
Deze studie onderzocht de effecten van een klassikale interventie op verschillende domeinen van beginnende geletterdheid. De interventie bestond uit het gezamenlijk lezen van digitale boeken via een SMARTboard gecombineerd met een verwijzingstechniek naar tekst. Het specifieke doel van de studie was…
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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From pixels to patterns: AI-driven image analysis in multiple domains
This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.
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The origins of friction and the growth of graphene, investigated at the atomic scale
Promotor: J.W.M. Frenken
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Gauge theory and nematic order : the rich landscape of orientational phase transition
Promotor: J. Zaanen
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On a quest to discover where stellar-mass black holes merge: testing the AGN binary formation channel with spatial correlation analyses
The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.
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Instituut voor Wijsbegeerte
De staf van het Instituut voor Wijsbegeerte bestudeert alle aspecten van de filosofie. In ons onderzoek streven wij naar een vruchtbare interactie tussen systematische en historische benaderingen van de filosofie. Wij werken in een context van intensieve nationale en internationale samenwerking.
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Wiskunde
Bekijk de opleidingsvideo van Wiskunde en ontdek waarom Wiskunde universeel toepasbaar is. Met veel keuzemogelijkheden.
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Informatica
In de opleidingsvideo over de bachelor Informatica krijg je een goed beel van de studie en hoe het programma eruit ziet. Ontdek het hier.
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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DSE 2.0
DSE 2.0: Naar een optimaal ontwerp van complexe, gedistribueerde cyber-fysieke systemen
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Tracing the journey of the sun and the solar siblings through the Milky Way
Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown
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Coupled Electronic and Nuclear Dynamics at Interfaces of Artificial Photosynthesis Devices
Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.
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Advances in 2D Material Synthesis, Transfer, and Device Integration
This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.
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Jaap VisserWiskunde en Natuurwetenschappen
j.visser@biology.leidenuniv.nl | +31 71 527 2727
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Deekshitha DeekshithaWiskunde en Natuurwetenschappen
d.deekshitha@liacs.leidenuniv.nl | 071 5272727
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Yuxuan ZhaoWiskunde en Natuurwetenschappen
y.zhao@liacs.leidenuniv.nl | +31 71 527 4799
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Weikang WengWiskunde en Natuurwetenschappen
w.weng@liacs.leidenuniv.nl | +31 71 527 4799
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Efficient Constraint Multi-Objective Optimization with Applications in Ship Design
Promotie
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Bijna 19 miljoen euro voor ontwikkelen en bestuderen van ‘organs-on-chips’
Het klinkt futuristisch, maar het kan toch: miniatuurorganen van patiënten maken en hierin bestuderen hoe ziektes zich ontwikkelen en behandeld kunnen worden. Dat willen onderzoekers van het LUMC, de Universiteit Twente (UT), UMCG, TU Delft en het Hubrecht Instituut de komende 10 jaar bereiken met een…
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Investigating lipid formulations for efficient RNA delivery using zebrafish models
Promotie
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Photosynthetic light reactions at the gold interface
Promotor: T.J. Aartsma, Co-promotor: R.N. Frese
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.