In this work, we attempt to answer the question:

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotor: K.J. Batenburg

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Het Center for Legal Entrepreneurship and Innovation (CLEI) richt zich op het stimuleren van ondernemerschap en innovatie in de juridische bedrijfstak.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Didactiek

Promotor: Prof.dr. H.A.G. Wijshoff

Deze maand publiceerde Johan Christensen, assistent professor aan het Instituut Bestuurskunde, zijn nieuwe boek: 'The Power of Economists within the State. In het boek analyseert hij waarom bepaalde landen verschillend beleid ten opzichte van economische deregulatie hebben geïmplementeerd. Daartoe onderzoekt…

Het Platform for Arts Research in Collaboration (PARC) is een nieuw online en offline platform voor onderzoekers die werkzaam zijn op het gebied van compositie, muziek, kunst en design en daarbuiten, om kennis, ervaringen en openbare evenementen uit te wisselen, samenwerking te stimuleren en de zichtbaarheid…

Welke kansen en bedreigingen vloeien voort uit de institutionele en normatieve diversiteit op het terrein van de rechten van de mens voor de effectieve bescherming van die rechten in een wereld die gekenmerkt wordt door pluralisme?

Terroristische groepen passen zich aan veranderingen in hun omgeving aan om relevant te blijven. Dit project biedt nieuwe inzichten door een theorie over strategische doelwitselectie te ontwikkelen en big data-analyse en machine learning toe te passen om de hypothesen te testen.

Hoe en in welke mate beïnvloedt AI de vertegenwoordiging van burgers in openbare dienstverlening en interacties tussen staat en burger?

Promotores: H.W. Lenstra, A. Lucchini

Stress komt veel voor in de huidige samenleving. Dit is zorgwekkend, aangezien onderzoek herhaaldelijk heeft aangetoond dat stress een negatieve invloed heeft op de lichamelijke gezondheid. Zo vergroot stress bijvoorbeeld de kans op hart- en vaatziekten.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Het Center for Interdisciplinary Placebo Studies Leiden (IPS) streeft naar een beter begrip van placebo- en nocebo-effecten, hun onderliggende mechanismen en hun mogelijke toepassingen in de klinische praktijk. IPS bestaat uit een groep interdisciplinaire onderzoekers die werken aan de Universiteit…

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Op 19 mei 2016 verdedigt Rosmarijn van Kleef haar proefschrift getiteld: Liability of football clubs for supporters’ misconduct. A study into the interaction between disciplinary regulations of sports organisations and civil law'.

This thesis mainly focuses on multimodal understanding and Visual Question Answering (VQA) via deep learning methods. For technical contributions, this thesis first focuses on improving multimodal fusion schemes via multi-stage vision-language interactions.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotores: Wim Jiskoot; Ferry Ossendorp

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Waar gaan de quantummechanica, de relativiteitstheorie en de zwaartekracht elkaar vinden? Wat is het missende stukje? Of is er een compleet nieuwe theorie die alle vormen van materie elegant beschrijft?

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

De docenten aangesloten bij Inclusief Leiderschap voor Depolarisatie zijn onder andere:

Promotores: F.H.J. Redig, W.T.F. den Hollander

Heart failure is a major health care problem with high mortality.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.

Dirk Broekhuijsen is op donderdag 16 november 2017 gepromoveerd op zijn proefschrift ‘A multilateral tax treaty: designing an instrument to modernise international tax law’. Zijn promotoren zijn prof. mr. F.A. Engelen en prof. mr. S.C.W. Douma.

Hieratic Papyrology

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

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