Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotor: J.M. Memelink

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

NEARCH beoogt de verschillende dimensies van publieksparticipatie binnen de hedendaagse archeologie te onderzoeken en nieuwe manieren van werken en samenwerken in kaart te brengen voor het vakgebied.

In november 2020 is het Engelstalige boek ‘Financial Collateral; Law and Practice’ verschenen. Het boek is gepubliceerd door Oxford University Press en geredigeerd en geschreven door professor Matthias Haentjens. Voorts hebben meegeschreven Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

Promotor: E.F. Smets, Co-promotor: J. Geml

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

A new publication on changes in the relationship between news and their public in Chile

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Onderzoek van de sectie Methodologie & Statistiek van het Instituut Psychologie aan de Universiteit Leiden

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Prof.dr. J. Memelink

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Promotor: Prof.dr. B. van de Water

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

In 2019 startte LUGO een petitie met het verzoek om een ambitieuze duurzaamheidsvisie voor 2030. Deze petitie is geformuleerd op basis van wat LUGO haalbaar achtte in plaats van op de beperkingen van nu. Wij vinden dat duurzaamheid een van de kernwaarden moet zijn van het volgende centrale beleidsplan…

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.