Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotor: Prof.dr.ir. E. Deprettere

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Op 5 juni 2018 verdedigde Emile Beenakker zijn proefschrift getiteld ‘The implementation of international law in the national legal order: A legislative perspective’. Het promotieonderzoek is begeleid door promotor professor W.J.M. Voermans.

Dit artikel verkent het complexe onderwerp vuurwapengeweld en benadrukt het belang van het opnemen van niet-dodelijke incidenten van vuurwapengeweld.

Dit artikel introduceert een nieuwe dyadische benadering om stemgedrag in de Raad van de Europese Unie te bestuderen.

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Op 12 september 2019 verdedigde Michiel Rhoen zijn proefschrift 'Big Data, Big Risks, Big Power Shifts: Evaluating the General Data Protection Regulation as an instrument of risk control and power redistribution in the context of big data'. Het promotieonderzoek is begeleid door promotoren prof.dr.mr.…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

Een verhaal van Twee Mosuls, De wederopstand van de Irakese strijdkrachten en de militaire nederlaag van ISIS. In dit artikel, gepubliceerd in het Journal of Strategic Studies, bespreken de auteurs Maarten Broekhof, Martijn Kitzen en Frans Osinga de militaire aanpassing door de Iraakse strijdkrachten…

Op 7 september verdedigde Francesc Claret Traid het proefschrift 'On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies'. Het promotieonderzoek is begeleid door Afshin Ellian en Gelijn Molier.

Op 9 januari 2019 verdedigde Marieke Wierda haar proefschrift 'The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries'. Het promotieonderzoek is begeleid door promotoren prof. dr. C. Stahn en prof.dr. L.J. van den Herik.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Dit artikel geeft antwoord op de vraag: Hoe kunnen we de ontwikkeling van eco-labels gestructureerder en transparanter maken?

Hoe beïnvloedt de vernietiging van universiteiten in Gaza, ook wel 'scholasticide' genoemd, het wetenschappelijk leven en wat zijn de theoretische en juridische onderbouwingen van de term?

Het The Hague Program for Cyber Norms, een onderzoeksprogramma van het Institute of Security and Global Affairs, heeft zijn eerste beleidsnota gepubliceerd. Hierin onderzoeken Dennis Broeders, Sergei Boeke en Ilina Georgieva de rol van inlichtingendiensten in cyberspace en de (on)mogelijkheden van adequate…

Promotor: Prof.dr. J.N. Kok

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Including modelling as part of software development appears to have various benefits.

The overarching goal of this PhD thesis is to investigate the taxonomic and functional diversity of yeasts in the wheat phyllosphere and their interactions with the mycotoxigenic fungal pathogen Fusarium graminearum.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: P.D. Grünwald