Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Wij hebben maar één maan, maar wist je dat sommige planeten er heel veel hebben? Jupiter bijvoorbeeld heeft er meer dan negentig! Kun je je voorstellen hoe de hemel eruit ziet voor een alien die op Jupiter woont? Een van die manen is Europa, die waarschijnlijk een oceaan van vloeibaar water heeft onder…

Nederland en China kunnen van elkaar leren slimmer om te gaan met afvalwater uit huishoudens en veeteelt. Leidse, Wageningse en Chinese wetenschappers gaan samen met betrokkenen werken aan haalbare oplossingen die milieu, gezondheid en economie vooruit helpen.

Promotores: H.A. Udo De Haes, P.M. Brakefield

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Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: G. J. Kroes

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Dissociative chemisorption is an important reaction step in many catalytic reactions.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

Promotor: Prof.dr. M. Ubbink

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

This thesis introduces the concept of

Promotor: Prof.dr. J.P. Abrahams

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

We gingen het water op! Op zaterdag 30 augustus 2025 gingen onze studenten samen met Plastic Soup Surfer Merijn Tinga de Leidse grachten op om te suppen én afval uit het water te vissen.

Op termijn zullen alle gebouwen een duurzame manier verwarmd en gekoeld worden, waardoor gas niet meer nodig is.

Io is één van manen van Jupiter, de grootste planeet in het zonnestelsel. Jupiter heeft wel negentig manen. Vier daarvan zijn veel groter dan de andere, en van die vier staat Io het dichtst bij Jupiter. Van de andere manen staan er maar vier nog dichter bij Jupiter.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Het dorp waar ik opgegroeid ben lag midden tussen de weilanden allemaal netjes begrensd door sloten. Op 10 minuten fietsafstand van mijn huidige woonplek is dit kenmerkende landschap eveneens te vinden.