Dit proefschrift onderzoekt de noodzaak van het creatief denken en experimenteren in het uitvoeren van complexe muziek in de late twintigste- en vroege eenentwintigste eeuw.

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: Prof.dr. P. Stevenhagen

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotor: J.W.M. Frenken

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Promotor: A. Kros

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Onderzoek aan LUC past binnen het algemene kader van de wereldwijde uitdagingen die centraal staan in ons onderwijsprogramma. Het richt zich op belangrijke maatschappelijke vraagstukken, waaronder Vrede & Recht, Diversiteit, Welvaart en Duurzaamheid.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

Promotor: J. Aarts

Promotor: Prof.dr. H.J.A. Rottgering

Technologies that help to enhance our educational environments can be found everywhere.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Sinds de oprichting is LUC een college voor onderwijsontwikkeling en experimentatie. In de missie van het college wordt LUC beschreven als "een plek van innovatie op het gebied van didactiek, curriculumontwerp en studentwelzijn." Deze visie wordt toegepast via een studentgerichte benadering in het onderwijs…

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

De komst van nieuwe wereldmarktspelers als India, Brazilië, China, Turkije en de Golfstaten geeft Afrikanen meer keuze met wie ze samen willen werken, en onder welke voorwaarden. Tegelijkertijd kiezen Afrikaanse multinationals ervoor met regionale partners te werken en oude politieke idealen te voorzien…

Het jaar 2017 was het Leiden Asia Year. Leiden heeft al eeuwenlang banden met en kennis over het continent, en het afgelopen jaar werden daar de spotlights op gezet.

Na Zhou (PhD bij het ICLON) onderzocht hoe docenten in het beroepsonderwijs leren tijdens stages in het bedrijfslven en hoe ze deze kennis toepassen op school. Promotie op 1 maart.