Promotor: E.F. Smets, Co-promotor: T.R. van Andel

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

We consider the propagation of electrical signals through nerve fibres.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Promotor: P.D. Grünwald

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Langetermijnontwikkelingen, zoals het verouderen van de bevolking, de toename in de gemiddelde levensverwachting en de gevolgen van de recente financiële crisis, hebben bijgedragen aan de discussie rondom de houdbaarheid van het pensioenstelsel.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Promotor: F. Arbab

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…