De programmagroep Neuropedagogiek en ontwikkelingsstoornissen heeft expertise in de ontwikkeling van kinderen en adolescenten, met de nadruk op ontwikkelingsstoornissen.

Het onderzoek van de sectie Sociale, Economische en Organisatiepsychologie is gericht op het ontwikkelen van modellen om beïnvloeding in sociale systemen te beschrijven en te verklaren. Dit wordt onderzocht binnen het domein Sociale en Organisatiepsychologie, en ook binnen de Economische en Consumen…

Is het brein van de rechter in staat om bewijs (DNA, camerabeelden) zo te interpreteren dat de waarheid wordt gevonden? Wat betekenen afwijkingen in het brein van de verdachte voor diens toerekeningsvatbaarheid? Kunnen we het brein van veroordeelden zo beïnvloeden dat ze niet zullen recidiveren? Deze…

Sinds april heeft de Faculteit der Sociale Wetenschappen er een nieuwe locatie bij voor haar onderzoek. Het Levelgebouw (direct naast Leiden Centraal) ontvangt proefpersonen in 3 gloednieuwe laboratoria. Psychologen Carsten de Dreu en Mariska Kret vertellen enthousiast over de nieuwe mogelijkheden voor…

Studies naar perceptuele besluitvorming presenteren dezelfde stimulus doorgaans herhaaldelijk tijdens een experimentele sessie, maar negeren de volgorde van deze observaties, waarbij wordt uitgegaan van een onrealistische stabiliteit van beslissingsstrategieën tijdens proeven. Maar zelfs ‘stabiel’,…

Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as meditation and yoga.

Nauwkeurig emoties van anderen herkennen is een essentiële sociale vaardigheid, die relevant is voor het omgaan met de sociale wereld vanaf de kindertijd. Het vermogen van kinderen om dit te doen is een mijlpaal in hun sociaal-emotionele ontwikkeling en wordt geassocieerd met een aantal belangrijke…

Elke dag nemen we vele beslissingen; van wat we eten tot hoe we de wereld om ons heen interpreteren. Over het algemeen gingen onderzoekers ervan uit dat een belangrijk onderdeel van ons besluitvormingsproces, namelijk het beslissingscriterium, stabiel blijft. Er zijn echter steeds meer aanwijzingen…

Een belangrijke uitdaging in de neurowetenschappen is het begrijpen hoe neuronen in honderden onderling verbonden hersengebieden sensorische input integreren met eerdere verwachtingen om bewegingen te initiëren en beslissingen te nemen.

Voor wie geïnteresseerd is in de relatie tussen neuro-cognitieve en biologische factoren enerzijds en leren, gedrag en emoties anderzijds.

Mensen met een licht verstandelijke beperking (LVB) bevinden zich dikwijls in een soort niemandsland. Door de diversiteit van hun problemen doen deze mensen een beroep op uiteenlopende hulpverleningsinstanties van waaruit ze weer worden doorverwezen. Hierdoor krijgen ze vaak niet de ondersteuning die…

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotor: E.F. Smets, Co-promotor: J. Geml

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Promotor: W.T. de Groot

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Promotor: R. Cramer

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

This dissertation presents new cryptographic protocols, which can be divided into two families.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa