1,320 zoekresultaten voor “quantum mechanisms” in de Publieke website
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Optical cavities and quantum emitters
Promotie
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Interesse in duurzame innovaties en data?
Ben jij nieuwsgierig naar hoe wetenschap en technologie bijdragen aan een duurzame en innovatieve toekomst? Bij de Universiteit Leiden onderzoek je de wereld van data, natuurwetten en levende systemen. Van wiskunde tot kunstmatige intelligentie, van klimaatvraagstukken tot hightech innovaties: je leert…
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Onderzoek
Computers worden steeds krachtiger en krijgen steeds ingewikkelder taken. Het Leiden Institute of Advanced Computer Science (LIACS) doet baanbrekend wetenschappelijk onderzoek en past nieuwe vindingen toe in actuele maatschappelijke vraagstukken.
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Interesse in duurzame innovaties en data?
Ben jij nieuwsgierig naar hoe wetenschap en technologie bijdragen aan een duurzame en innovatieve toekomst? Bij de Universiteit Leiden onderzoek je de wereld van data, natuurwetten en levende systemen. Van wiskunde tot kunstmatige intelligentie, van klimaatvraagstukken tot hightech innovaties: je leert…
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Archief
Op deze pagina vind je de opnames van de Tuesday Talks sinds april 2025. Ook de opnames van de voorloper van de Tuesday Talks, This Week’s Discoveries, zijn hier te vinden
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Prijzen en subsidies 2023
Op deze pagina vind je een overzicht van prijzen en subsidies die in 2023 zijn toegekend aan onze medewerkers en studenten, en de bijzondere benoemingen aan de Universiteit Leiden en andere instellingen.
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Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
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Studenten programmeren met qubits
Als eersten ter wereld hebben studenten van de Leidse master Computer Science les gehad in het programmeren van een quantumcomputer. ‘Hiermee zijn eindelijk de complexe levensechte problemen van de maatschappij op te lossen.’
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Twee ERC Consolidator Grants voor Leidse wetenschappers
Onderzoek naar quantumcomputers en islamitische goede doelen: twee Leidse wetenschappers krijgen een Consolidator Grant van de European Research Council.
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Spin transport and superconductivity in half-metallic nanowires and junctions
The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.
- Over deze minor
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Online Course International Law in Action: The Arbitration of International Disputes
This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…
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Anna Dawid-LekowskaWiskunde en Natuurwetenschappen
a.m.dawid@liacs.leidenuniv.nl | +31 71 527 2727
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Huub de GrootWiskunde en Natuurwetenschappen
h.j.m.de.groot@lic.leidenuniv.nl | 071 5274539
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Photocatalytic redox reactions at the surface of liposomes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Thrips resistance in Gladiolus: an eco-metabolomic approach
Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Het lerarentekort als gewichtige uitdaging: Schoolleiderschap, werkklimaat en leerklimaat op scholen met een hoge schoolweging.
Welke rol spelen de leiderschapsstijl en de visie op leraren en leerlingen van schoolleiders in het bevorderen van een positief werkklimaat voor leraren en een positief leerklimaat voor leerlingen op scholen met een hoge schoolweging?
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Regulering en ICT
Op welke manieren hebben ontwikkeling van digitale technologieën invloed op de samenleving en de regulerings- en juridische kaders binnen de samenleving?
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Verhalen van vrouwen uit de natuurkunde: ‘Ik wil weten hoe de wereld werkt’
Voor de Internationale Dag van Vrouwen en Meisjes in de Wetenschap vertellen vrouwelijke studenten en onderzoekers uit de natuurkunde over wat hen inspireert in hun werk. Van kwantum tot kosmologie en biofysica, hun nieuwsgierigheid naar hoe de natuur werkt is wat deze vrouwen verbindt. Wat willen deze…
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Waar eindigt de quantumwereld?
Met zijn ijskoude nanokrachtsensor zoekt Tjerk Oosterkamp naar de grens tussen de quantumwereld en de wereld van alledag. De Leids natuurkundige heeft een NWO-subsidie van 600.000 euro binnengehaald.
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Nacht van Ontdekkingen in teken van de tijd
Is teleportatie het vervoermiddel van de toekomst? Welke invloed had de 16e-eeuwse geleerde Scaliger op het besef van tijd? Ontdek het in de Nacht van Ontdekkingen op zaterdag 15 september in Leiden! Wetenschappers geven flitscolleges en buigen zich samen met het publiek, kunstenaars en muzikanten over…
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Contact
Algemene contactinformatie
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Causing a stir: Radiative and mechanical feedback in starburst galaxies
Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf
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Some Assembly Required: The Structural Evolution and Mass Assembly of Galaxies at z
This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Electrocatalytic reduction of CO2 and nitrate on immobilized metal porphyrins
M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid
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CO oxidation catalysis at multiple length scales
Promotor: J.W.M. Frenken Co-Promotor: R. Felici
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Florian Schneider
Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?