This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Een team van onderzoekers, onder wie chemicus Mario van der Stelt, heeft een nieuwe manier ontdekt om een van de menselijke kernreceptoren te blokkeren. De onderzoekers verwachten dat hun vinding een flinke impact heeft in de wereld van medicijnonderzoek. Publicatie in Nature Communications.

Weinig onderzoekers zien heil in onderzoek naar glioblastoom, een ongeneselijke hersentumor. Alexander Kros bracht collega’s bij elkaar die de uitdaging aangaan. Europese onderzoeksfinancier ERC stelde onlangs 10,6 miljoen euro ter beschikking, een jaar eerder stelde NWO 3 miljoen euro beschikbaar.…

Chronische pijn, misselijkheid of braken door chemotherapie. Als je er last van hebt, kan medicinale cannabis een uitkomst zijn. Het nadeel is alleen wel dat patiënten er high van kunnen worden. Leidse onderzoekers van het Oncode Instituut doen daarom onderzoek naar alternatieven waar je dat niet van…

Curved single crystals provide variable, but well-defined surface structures.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotor: A. Kros

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

The role of the interfacial environment during electrochemical reactions has been increasingly valued, especially for those reactions involving protons or hydroxyl ions.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Naar schatting bestaat de wereldbevolking over twintig jaar uit ongeveer 8,7 miljard mensen, terwijl dat aantal nu 7,3 miljard is. Deze groei, gecombineerd met de bijbehorende groei in consumptie en de verbeteringen in levensstandaarden, zal resulteren in een enorme groei in de vraag naar voedsel, verbruiksgoederen,…

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

Deze tweejarige masteropleiding wordt aangeboden door het Leiden Institute of Chemistry en heeft een focus op technologische en fundamentele kennis en expertise. Tijdens de opleiding doe je onderzoek naar de processen van de levende cel met fundamenteel wetenschappelijke én toegepaste technologie. Je…

Hoe passen bacteriën zich aan aan een nieuwe leefomgeving? Hoe zitten genomen van bacteriën precies opgevouwen in cellen? Dat gaat een internationaal team van wetenschappers onderzoeken, onder leiding van de Leidse biochemicus Remus Dame. Het Human Frontier Science Program heeft hiervoor een subsidie…

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

Promotor: Prof.dr. G.J. Kroes

Promotor: Prof.dr. H.S. Overkleeft

How can we bridge the gap between experts and the general public?

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Welke schimmels leven in de historische gebouwen en collecties van de Universiteit Leiden, hoe beïnvloeden deze schimmels erfgoed en gezondheid, en hoe kunnen we ze beter begrijpen en beheersen?

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Een van de belangrijkste onderzoeksthema’s van de Hortus botanicus Leiden is het begrijpen van de evolutie van biodiversiteit. Hoe zijn plantensoorten in de loop van de tijd ontstaan, veranderd en gediversifieerd? De Hortus bestudeert de relaties tussen soorten binnen specifieke plantengroepen en onderzoekt…

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.