Promotores: A.H. Meijer, H.P. Spaink

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Promotor: Prof.dr. J.N. Kok

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotie

Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?

Dit project onderzoekt hoe mensen taalvormen zoals vragen of beweringen kiezen in het dagelijks spraakgebruik.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Control of infectious diseases poses continuous challenges for human health.

By drawing on the personal experiences of contributors based in different institutions and countries, the articles in this special issue provide a fairly broad overview of ethics practices and concerns in different localities (though not globally, as we had originally hoped), showing, as one student…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Prof. Herman P. Spaink heeft een subsidie gekregen om te screenen voor nieuwe geneesmiddelen tegen tuberculose. Deze subsidie voor de verdere ontwikkeling van robottechnologie voor grootschalige geneesmiddelenscreening was mogelijk dankzij donaties van Leidse alumni.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Deze bundel onderzoekt sociale betekenis vanuit het perspectief van actuele theorieën in de pragmatiek.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

De examencommissie van de Honours Academy stelt vast of de student voldoet aan de eisen van het desbetreffende honoursprogramma en behandelt uitzonderingsverzoeken.

Een onderzoek naar hoe mensen eten en drinken tijdens hun dagelijkse routines, en onder welke omstandigheden dit plaatsvindt.

Woorden kunnen, afhankelijk van wie ze waar en wanneer gebruikt, erg veel verschillende betekenissen hebben of zelfs het tegenovergestelde van hun woordenboekbetekenissen uitdrukken.

Hoe beïnvloeden sociale en politieke ontwikkelingen het proces van betekenisgeving in verschillende delen van de wereld? Waarom is een bepaald discours op verschillende manieren te interpreteren, afhankelijk van de context waarin deze wordt geproduceerd en overgedragen? En hoe zijn cultuur, politiek,…

Semantiek en pragmatiek vormen samen de studie van de betekenis van taal.

Promotie

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Promotores: H.A. Udo De Haes, P.M. Brakefield