1,350 zoekresultaten voor “induced pluripotent stem cells” in de Publieke website
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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Determining the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Hessel wil jongeren weer een stem geven: ‘Belangrijk om met elkaar in contact te komen’
Van collegebank tot raadszetel. In aanloop naar de gemeenteraadsverkiezingen van 14, 15 en 16 maart 2022 stellen we FGGA-studenten en alumni die in hun gemeente op de kandidatenlijst staan, aan je voor. Welke ambities hebben ze? Wat heeft hun studie aan hun politieke werk bijgedragen en waar zien ze…
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Unraveling cross-presentation pathways using a chemical biology approach
Kasteren
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Prof.dr. A.M. Dogterom in DWLD
Hoe vermenigvuldigen de miljoenen cellen in ons lichaam zich precies? Prof. Dogterom legt uit hoe zij een onderdeel van een cel heeft kunnen nabouwen op een chip met deeltjes ter grootte van een nanometer.
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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AMPK Signaling in Dendritic Cells
Promotie
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Chemische verbinding beïnvloedt afweersysteem
Chemici, waaronder Sander van Kasteren en Hermen Overkleeft, hebben ontdekt dat azides, een bepaalde chemische verbinding, specifieke T-cellen kunnen laten reageren op een vaccin of juist het vaccin kunnen laten negeren. Publicatie in Angewandte Chemie.
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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Stamcellen als remedie
Leiden heeft een lange geschiedenis in het behandelen van bloedcelkanker. Het onderzoek naar betere therapieën staat nooit stil. Er wordt nu onder meer gewerkt aan een ‘levend geneesmiddel’.
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
- Life Science & Technology
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Beerend Hierck
3D en peer review.
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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The noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
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Biophysical feedbacks between seagrasses and hydrodynamics in relation to grazing, water quality and spatial heterogeneity
Consequences for sediment stability and seston trapping
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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The ecological relevance of chemical diversity in plants
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Understanding the role of mycorrhizas in global carbon cycle processes
How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?
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Neonicotinoids in nature: The effects on aquatic invertebrates and their role in ecosystems
This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.
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Magnetic Resonance Force Microscopy and the Spin Bath
There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.
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Nanofluidic tools for bioanalysis : the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
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Fate, accumulation and impact of metallic nanomaterials in the terrestrial environment
The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.
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Agenda dynamics in the European Union : the interaction between the European Council and the European Commission in the policy domain of organized
The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Impact of insect herbivory and microbial inoculants on the rhizosphere microbiome and volatilome
This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…
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Een slechte nier herstellen of een nieuwe nier op bestelling
Zoeken naar manieren om de noodzaak tot niertransplantatie te vertragen en proberen om nieren op maat te bouwen.
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Unfolding the principles of genome folding and dynamics in bacteria
Remus Dame
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Exploiting vulnerabilities induced by recurrent mutations in chondrosarcoma and giant cell tumour of bone
Promotie
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Aansluiting bij het onderwijs
Het practicum en de lessenserie sluiten aan bij verschillende thema’s in de lesmethode.
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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How T cells talk to the neighborhood
Promotie
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David wil studenten in Leiden een stem geven: ‘Leerzaam en leuk om een eigen partij op te richten’
Van collegebank tot raadszetel. In aanloop naar de gemeenteraadsverkiezingen van 16 maart 2022 stellen we FGGA-studenten en alumni die in hun gemeente op de kandidatenlijst staan, aan je voor. Welke ambities hebben ze? Wat heeft hun studie aan hun politieke werk bijgedragen en waar zien ze zichzelf…
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Life Science and Technology (BSc)
Bij de bacheloropleiding Life Science and Technology leer je de biologie van de cel doorgronden, en leer je ingewikkelde problemen op een efficiënte en systematische manier oplossen.
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Kankercellen onder de loep
Waarin verschilt een tumorcel van een gezonde cel? Die vraag proberen onderzoekers zo precies mogelijk te beantwoorden. Sommige verschillen kunnen dienen als aangrijpingspunt voor nieuwe therapieën.
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De levensloop: van 1 cel naar 14.000.000.000 cellen
Workshop | Leiden2022
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Ariane Briegel: 'Met AI gaat letterlijk een wereld open voor de levenswetenschappen'
Bacteriën op heterdaad betrapt, diep bevroren terwijl ze op het punt stonden de ziekte van Lyme te veroorzaken. Razend enthousiast is Ariane Briegel over wat ze allemaal kan zien dankzij de drie-eenheid van een vriestechniek, een microscoop met camera en kunstmatige intelligentie. 'Het is fascinerend,…
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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Understanding membrane fusion at the molecular level using a biomimetic model system
Kros
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
- Epigenetica: of waarom een lapjeskat een lapjeskat is