489 zoekresultaten voor “computational biology” in de Publieke website
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Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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regular and deuterated water in space: a combined laboratory and computational study
Promotor: Prof.dr. H.V.J. Linnartz
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Kersverse hoogleraar Gerard van Westen wil grenzen doorbreken
Kersverse hoogleraar Gerard van Westen werkt op het snijvlak van kunstmatige intelligentie en medicijnontwikkeling. Voor de nieuwe leerstoel Artificial Intelligence and Medicinal Chemistry zet hij computermodellen in om medicijnontwikkeling efficiënter te maken. ‘ Ons ultieme doel is een virtuele mens…
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Topology and Geometry in Chiral Liquids
We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.
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Kevin Groen
Wiskunde en Natuurwetenschappen
k.groen@cml.leidenuniv.nl | +31 71 527 6822
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Meiru Wang
Wiskunde en Natuurwetenschappen
m.wang@cml.leidenuniv.nl | +31 71 527 2727
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Remko Offringa benoemd tot Opleidingsdirecteur masteropleiding Biology
Dr. Remko Offringa is met ingang van 1 september 2016 benoemd tot Opleidsingsdirecteur van de masteropleiding Biology. Hij volgt daarmee Johan Memelink op.
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Computability of the étale Euler-Poincaré characteristic
Promotor: S.J. Edixhoven, L.D.J. Taelman
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Dubbel succes bij de EMBL Chemical Biology Conference
Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.
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context-based educational reform practical for implementatiion in Dutch biology education
Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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Kees Musters
Wiskunde en Natuurwetenschappen
musters@cml.leidenuniv.nl | +31 71 527 7461
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Louie Krol
Wiskunde en Natuurwetenschappen
l.krol@cml.leidenuniv.nl | +31 71 527 2727
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Prof.dr. Geert de Snoo benoemd tot hoogleraar Conservation Biology
Prof.dr. Geert de Snoo is per 1 maart bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Conservation Biology. De Snoo blijft hoofd van de gelijknamige afdeling van het Institute of Environmental Sciences (CML).
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Fan Zhang
Wiskunde en Natuurwetenschappen
f.zhang@cml.leidenuniv.nl | +31 71 527 5615
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Chengyi Liu
Wiskunde en Natuurwetenschappen
c.liu@cml.leidenuniv.nl | +31 71 527 2727
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Studenten Honours Course Geology & Marine Biology schenken geweldig grote ammoniet aan de faculteit
In het kader van de Honours Course ‘Crises in Biology’ die plaatsvond van 19 augustus t/m 2 september 2012 in Normandië, bezochten studenten vele geologische interessante locaties. Een van deze bijzondere plekken was de kust van Arromanches. Hier bemachtigden zij een enorm grote ammoniet die ze dinsdag…
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Bregje Brinkmann
Wiskunde en Natuurwetenschappen
b.w.brinkmann@cml.leidenuniv.nl | +31 71 527 7475
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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The developing infant gut microbiota: mathematical predictions of the effects of oligosaccharides
A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Assistant/Associate professor in Quantitative Ecology (0.8-1.0 fte)
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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Interactions of nutrients and pesticides and their effects on aquatic macrofauna
Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?
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Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Peptide amphiphiles and their use in supramolecular chemistry
Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Philipp Kropf
Wiskunde en Natuurwetenschappen
p.kropf@cml.leidenuniv.nl | +31 71 527 2727
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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The tension between nature conservation and economic valuation of ecosystem services
Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Daniel Zumel Gete
Wiskunde en Natuurwetenschappen
d.zumel.gete@cml.leidenuniv.nl | +31 71 527 2727
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Anagnostis Theodoropoulos
Wiskunde en Natuurwetenschappen
a.theodoropoulos@biology.leidenuniv.nl | +31 71 527 4882
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Peter van Welzen
Wiskunde en Natuurwetenschappen
peter.vanwelzen@naturalis.nl | +31 71 527 2727
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Sam Boerlijst
Wiskunde en Natuurwetenschappen
s.p.boerlijst@cml.leidenuniv.nl | +31 71 527 2727
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…