1,178 zoekresultaten voor “stem cell biology” in de Publieke website
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft Aerts
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Stemmen van Afrika
Voor groep 7/8 basisschool en klas 1/2 voortgezet onderwijs.
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Terpenoids and terpenoid indole alkaloids in Catharanthus roseus cell suspension cultures
Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte
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systems and unsupervised computing: exploration of applications in biology
In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.
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Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.
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Unraveling cross-presentation pathways using a chemical biology approach
Kasteren
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Towards in-cell structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Understanding and Targeting Coronaviruses Exploring advanced cell culture models and host-directed antiviral strategies
Promotie
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Broadening Youth Participation in STEM Learning
How can we broaden youth participation in STEM Learning
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Andeweg & Leyenaar, Alle stemmen tellen!
Een twintigtal Nederlandse politicologen buigt zich over de oorzaken, gevolgen en vooruitzichten van het algemeen kiesrecht in Nederland. Liep Nederland voorop of juist achteraan bij de invoering van kiesrecht voor mannen en iets later voor vrouwen? Hoe hebben burgers de afgelopen eeuw gebruik gemaakt…
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Comparative biology of common and grey seals along the Dutch coast
What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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unchained; molecular mechanisms of ubiquitin-like signal transduction in cell cycle progression
Promotie
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Research and design in STEM education
Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…
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Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Cel analyseren op atoomniveau met Cell Observatory
Details kunnen zien van een zieke of gezonde cel, dat is mogelijk met de supermicroscoop van het consortium Cyttron. Niet alleen de microscoop is vernieuwend in zijn soort: ook de vorm waarop de partijen samenwerken past in de huidige tijd. “Toegang tot elkaars techniek, daar draait het om in ons samenwerkingsverband”,…
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Cell Observatory en labs voorzichtig van start
Met de nodige maatregelen starten onderzoekers hun werkzaamheden in verschillende laboratoria weer deels op. Het Leidse Cell Observatory is één van de plekken waar wetenschappers sinds 11 mei hun labwerk hervatten.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Kevin Groen
Wiskunde en Natuurwetenschappen
k.groen@cml.leidenuniv.nl | +31 71 527 6822
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Meiru Wang
Wiskunde en Natuurwetenschappen
m.wang@cml.leidenuniv.nl | +31 71 527 2727
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Remko Offringa benoemd tot Opleidingsdirecteur masteropleiding Biology
Dr. Remko Offringa is met ingang van 1 september 2016 benoemd tot Opleidsingsdirecteur van de masteropleiding Biology. Hij volgt daarmee Johan Memelink op.
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Dubbel succes bij de EMBL Chemical Biology Conference
Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.
- Onderzoeksfaciliteiten
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context-based educational reform practical for implementatiion in Dutch biology education
Docenten spelen een cruciale rol bij het implementeren van onderwijsvernieuwingen. Uiteindelijk hangt het succes van de implementatie af van de manier waarop docenten de vernieuwing vormgeven in hun dagelijkse lespraktijk.
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Theo Anagnostopoulos
Wiskunde en Natuurwetenschappen
t.anagnostopoulos@biology.leidenuniv.nl | +31 71 527 2727
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Regulators of integrin α6β4 function
This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.
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Kees Musters
Wiskunde en Natuurwetenschappen
musters@cml.leidenuniv.nl | +31 71 527 7461