Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

During the course of drug discovery translational steps are made.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotor: Prof.dr. J. Kuiper

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: C.J. ten Cate

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Op 29 april heeft een live viewing plaatsgevonden op de Spaanse Trappen van het Wijnhavengebouw in Den Haag van het ‘Spitzenkandidaten’-debat vanuit het Theater aan het Vrijthof in Maastricht tussen de kandidaten die door hun Europese politieke partij zijn aangewezen als kandidaat-voorzitter van de…

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

Promotor: G.P. van Wezel

Promotor: J. Kuiper

Including modelling as part of software development appears to have various benefits.

Promotor: J. Zaanen

Promotor: Prof.dr. C.U. Keller

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Promotores: T.H. Oosterkamp, N. de Jonge

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Wie Westerse media volgt, denkt al snel aan 'Afrika' als het herkomstoord van wanhopige migranten, continent van honger en ziektes, broedplaats voor internationaal terrorisme. Wie een breder beeld wil hebben, kan terecht bij de Leidse Afrikanisten. Juist door hun nauwe banden met Afrikaanse partners…

Rogier Creemers, universitair docent recht en bestuur van modern China praat in de BNR China Podcast mee over de macht en de toekomst van de Chinese techgiganten. Zij worden door de Chinese overheid steeds vaker op de vingers getikt. Maar waarom eigenlijk?

Enforcement of group cooperation fails because of discriminatory punishment, according to research by Welmer Molenmaker and colleagues. When group members have different backgrounds, punishment turns into a double-edged sword: no longer used just to prevent group exploitation, but also to break the…

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Ontdek het congres 'European Paediatric Ophthalmology Society' van Boerhaave Nascoling en leer over de nieuwste ontwikkelingen binnen kindoogheelkunde. Lees hier meer!