This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

Informatici Yu Liu, Yanming Guo en Michael Lew van de Universiteit Leiden zijn een stap dichterbij hun ultieme doel: zoekmachines met visuele herkenning. Hun publicatie van een nieuw algoritme voor het samenvoegen van multi-scale deep learning representaties is met groot enthousiasme ontvangen. Geen…

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Gedurende een periode van zeven jaar heeft een internationaal team van wetenschappers meer dan een kwart van de noordelijke hemel in kaart gebracht met behulp van de Low Frequency Array (LOFAR), een pan-Europese radiotelescoop. Vanuit Leiden zijn onder andere Astronoom Timothy Shimwell en Huub Röttgering…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Als zorgverlener komt u regelmatig in aanraking met patiënten die aangeven allergisch te zijn voor antibiotica. In deze online module leert u verschillende typen allergieën onderscheiden en dilemma’s uit de dagelijkse praktijk op te lossen.

Het blijkt dat de nieuwe minor S&RBB erg populair is onder de eerstejaars studenten.

Alvast oefenen in de boardroom en start ups door spannende tijden loodsen. Studenten van Harmen Jousma, docent Science Based Business, leren de kunst van het ondernemen al in de collegebanken. Jousma is een van de drie genomineerden voor de Leidse Onderwijsprijs.

Didactiek

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Vier Leidse studenten die de masterspecialisatie Science Based Business volgen, bedachten een concept om met een 3D Bioprinter menselijke huid te produceren. Slachtoffers van brandwonden zouden dankzij Skinprint minder operaties nodig hebben en er minder littekens aan over houden.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Toeval? Verpeegkundige Lucia de B. zou tijdens haar werk dertien mensen – waaronder een aantal baby’s – hebben vermoord: de kans dat deze mensen toevallig tijdens of vlak voor haar dienst spontaan zouden zijn overleden, werd in 2002 door een statisticus zo klein geacht dat er geen sprake kon zijn van…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Innovatieve principes van challenge-based learning combineren met ontwikkeling van lesprogramma’s.

Promotores: J. Kok, M. Chaudron (Chalmers University)

In een aflevering van de Tim en Paul Geschiedenis Podcast geeft Tristan Mostert uitleg over de VOC en de specerijenhandel.

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)