In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Bastiaan Rijpkema en Mariëtte Boon zijn geselecteerd door de jury van New Scientist als potentieel Wetenschapstalent van 2017. Vanaf 23 mei mag het publiek mee beslissen wie zich een jaar lang het New Scientist Wetenschapstalent mag noemen. Stem op een van onze kandidaten!

Help Marcia Brandenburg-Goddard om onderzoek naar autisme bij een breed publiek onder de aandacht te brengen. Stem daarom op Marcia en hopelijk wint zij de Publieksprijs van FameLab 2015!

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

Erdogan won deze week de presidentsverkiezingen in Turkije. In Turkije kreeg hij ruim 52 procent van de stemmen, in Nederland kreeg hij zo'n 73 procent. 'Het is een a-selecte groep die hier is gaan stemmen', legt Erik-Jan Zürcher uit. De hoogleraar Turkse talen en cultuur noemt daarvoor twee oorzake…

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Met AI-programma’s als Suno en Udio kun je liedjes componeren die verdacht veel weg hebben van de stijl en zang van bekende artiesten. Kunnen artiesten hier iets tegen beginnen?

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Leids alumnus Wil Stutterheim en biologiestudent Wouter Bruins zijn met In Ovo genomineerd voor de Herman Wijffels Innovatieprijs. Met uw stem maken ze kans op de publieksprijs.

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.