‘s Lands grootste kruidenier geeft om jongeren geen zier’, schreeuwt een spandoek tijdens een kantoorbezetting bij Ahold in 1981. ‘Werkende jongeren werden lang niet serieus genomen. Toch hebben ze zichzelf op de kaart gezet’, weet historicus Rosa Kösters.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Medewerkers en studenten van de Universiteit Leiden protesteren 25 november in Den Haag tegen de miljardenbezuinigingen op het hoger onderwijs. ‘Deze bezuinigingen zijn een heel slecht idee en dat willen we laten zien,’ zegt Claire Weeda van WOinActie. ‘Wetenschap en onderwijs zijn essentieel voor onze…

Promotor: P.M. Brakefield

Uit onderzoek van de NOS blijkt dat gokbedrijven, waaronder Holland Casino en de Nederlandse Loterij, meer invloed hadden dan verslavingsdeskundigen bij de totstandkoming van nieuwe regels over gokreclames.

Twee jaar geleden trad Ingrid van Engelshoven aan als minister op OCW. 'Academische onrust is het voorlopig resultaat van het beleid van deze D66-minister, dat zich kenmerkt door een volledig gebrek aan visie op wetenschap in brede zin,' betogen Leidse hoogleraren en D66-leden Hermen Overkleeft en Sjaak…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotie

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Promotores: Wim Jiskoot; Ferry Ossendorp

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Consequences for sediment stability and seston trapping

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: Roeland M.H. Merks

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The applications of studying the early development of insects range from agriculture to material science.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotores: A.H. Meijer, H.P. Spaink

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Promotor: J. Kuiper