This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?

Het Hazelhoff Centre for Financial Law onderzoeksprogramma voor 2020-20203 draait om de integriteit van financiële markten in tijden van crisis en de mogelijke manieren om deze integriteit te bewerkstelligen.

In dit boek wordt onderzocht hoe kunstmatige intelligentie (AI) internationale conflicten in cyberspace verandert.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

In this thesis I examine how soil biotic and abiotic characteristics change and interact throughout the course of afforestation and how they subsequently impact tree performance.

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

This thesis was embedded in the APELAFICO project and focussed on investigating effects of sound from North Sea offshore wind farms on pelagic fish and harbour porpoise.

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

Op 20 oktober 2021 verdedigde Michael Ramsden het proefschrift 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. Het promotieonderzoek is begeleid door promotor prof.dr. N.M. Blokker.

Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

The interest of this thesis lies in spin transport in normal metals and superconducting half-metallic junctions.

Van onderwijs tot een verrijkende ervaring

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Het belangrijkste doel van dit onderzoek is om de steden van het Romeinse Nabije Oosten in de keizertijd in kaart te brengen, met een focus op locatie, stadsgrootte en stedelijke kenmerken, om de vorm van het stedelijke systeem en de niveaus van integratie te bestuderen.

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Kunst en vrije tijd, Kunst en vrije tijd

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

Op 6 januari promoveert Kefan Bao. Het Leiden University Centre for Linguistics feliciteert Kefan!

Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…