In the first part of this thesis we study the geometry of folding patterns.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Patterned detectors are an existing technology that can be found in almost all color cameras.

In this thesis, we investigate how deep generative models (AI models that can create new designs) can be better utilized for technical and industrial design. Our goal is to generate designs that are not only realistic (plausible), but also efficient, reliable, and usable in complex 2D and 3D applica…

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Promotores: J. Kok, M. Chaudron (Chalmers University)

Wil je aan de slag met Designing Your Life-onderwijs? Deze website heeft alles wat je nodig hebt!

Bestuursprocesrecht in constitutioneel-rechtsvergelijkend perspectief.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

In 2021 heeft het NCSC de Universiteit Leiden gevraagd om een rapid review uit te voeren naar best practices en mogelijkheden voor vervolgonderzoek over de integratie van gedragswetenschappen in security by design methodologieën en projecten. Dit academische veld wordt security by behavioural design…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Promotor: Prof.dr. T.H.W. Bäck

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Technologies that help to enhance our educational environments can be found everywhere.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek

Bij onderwijsvernieuwing wordt vaak nascholing ingezet, maar die is niet altijd effectief. In haar proefschrift onderzocht Nienke Wieringa (ICLON) welke ondersteuning docenten nodig hebben bij onderwijsvernieuwing.

Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

In een korte presentatie vertelt een onderzoeker van de Faculteit der Wiskunde en Natuurwetenschappen over zijn of haar onderzoek.

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Promotor: Prof.dr. J.N. Kok

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Promotor: Prof.dr. A.W. van der Vaart

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

The project seeks to develop an eco-design framework for single-use medical devices and packaging

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.