All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotor: J.W.M. Frenken

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Het Institute of Security and Global Affairs (ISGA) biedt onderwijsprogramma’s aan op bachelor- en masterniveau. Tevens zijn er minoren, wordt er online onderwijs aangeboden en is er onderwijs voor professionals.

Het onderwijsaanbod van de Faculteit Governance and Global Affairs in Den Haag sluit nauw aan op de thema’s die de stad kenmerken als Internationale Stad van vrede, veiligheid en recht en als centrum van het Nederlandse openbaar bestuur en international governance.

Studievoorlichting

Hoe hebben humanitaire organisaties voorbereidings- en responsstrategieën voor cyberincidenten afgestemd op hun specifieke prioriteiten, behoeften en context?

In dit boek wordt onderzocht hoe kunstmatige intelligentie (AI) internationale conflicten in cyberspace verandert.

Studievoorlichting

Als onderdeel van je inschrijving voor de bachelor Security Studies doe je ook een Online Matchingsmodule.

These syntheses allow the team to determine the extent to which schools-based interventions are effective at targeting radicalisation-related outcomes.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Promotor: B. van de Water

Students Practicing Citizen Journalism

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotor: Prof.dr. S. Haring

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Promotores: H. Schiessel, G.T. Barkema

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: K.J. Batenburg

Promotor: Prof.dr. A.W. van der Vaart

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: J. Kuiper

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst