Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: J.W.M. Frenken

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Matthias Haentjens, Jouke Tegelaar en Dorine Verheij schreven het hoofdstuk Financial Market Regulation and Supervision, dat recentelijk is gepubliceerd in het belangwekkende handboek The Law of the European Union (voorheen Kapteyn & VerLoren van Themaat).

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

In een Advance Online Publication in Nature Structural & Molecular Biology laten biofysicus John van Noort en anderen zien dat DNA gevouwen zit in flexibele spiralen van chromatine. De onderzoeksgroep van Van Noort ontdekte dit in nauwe samenwerking met onderzoekers uit Cambridge. Het artikel met de…

Voor Molecular Science and Technology is de matchingsactiviteit een verplicht onderdeel van de inschrijving.

Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Planets are formed in disks of gas and dust around young stars.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

During the course of drug discovery translational steps are made.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.