Terwijl cocaïnevangsten in de Rotterdamse haven sterk dalen, exploderen de cannabisonderscheppingen, zegt emeritus-hoogleraar Pieter Tops in het AD.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Nature, nurture and neural mechanisms of social emotion regulation in childhood

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Ton van Haaften is met ingang van 1 maart benoemd tot Dean van de Honours Academy. Hij volgt Willemien den Ouden op, die sinds 1 september 2012 deze functie bekleedde.

In de Rotterdamse haven lekken kleine industriële deeltjes het milieu in. Dit leidt tot een vorm van vervuiling die moeilijk te traceren, maar zeer hardnekkig is. Drie studenten van het LDE Sustainability Honours Programme onderzochten in opdracht van de haven waar deze vervuiling vandaan komt.

Het is zonneklaar dat Rome verantwoordelijk is voor het vinden van een veilige haven, stelt onderzoeker Eugenio Cusumano.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Luuk Esser, universitair docent straf- en strafprocesrecht, was te gast in het het NPO1-programma Na Het Nieuws.

Vervolging, conflicten en crises bedreigen wereldwijd academische voorzieningen en onderzoekers. Dit heeft grote gevolgen voor de wetenschap. Het Scholars for Scholars-programma van de Universiteit Leiden helpt wetenschappers in nood door crowdfunding.

Van een optimaal ontworpen schip dat zelf aangeeft wanneer welk onderhoud nodig is, tot een intelligente reisplanner voor wereldwijd goederenvervoer. Het bruist op de drie Zuid-Hollandse universiteiten van het AI-onderzoek op haven- en maritiem gebied. Onderzoekers vertellen. Deel 2 van een serie over…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Bekend is dat drugs via Nederlandse havens gesmokkeld worden, maar bij Bulk Terminal Zeeland speelde iets bijzonders. Pieter Tops legt uit op NPO Radio 1.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: J. Zaanen, Co-Promotor: V. Juricic

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

This thesis discusses the discovery potential of Intensity Frontier experiments.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

Graduation MIRD Class of 2024: 'The world is better off with students like this'

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Congres/symposium, Call for papers

Op 10 januari promoveert Astrid van Winden. Het Leiden University Centre for Linguistics feliciteert Astrid!

Promotie

Studievoorlichting, On Campus Experience

Studievoorlichting, On Campus Experience

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Promotor: A. Kros

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.