De huidige nucleaire dreiging van Rusland is op verschillende punten te vergelijken met die ten tijde van de Cubacrisis, het hoogtepunt van de Koude Oorlog. Dat stelt emeritus hoogleraar Gert Oostindie in Trouw.

Bijna 1,8 miljoen kijkers zaten er zondagavond klaar voor: het RTL Verkiezingsdebat. Voor de eerste keer in dit verkiezingsseizoen kruisten zes lijsttrekkers op televisie de degens. Hoogleraar Journalistiek en retorica-expert Jaap de Jong maakt de balans op: ‘Geen grote grandeur, geen grote misère,…

Lezing

Op 29 februari verscheen er een column van Maaike Warnaar in de Volkskrant over de Iraanse verkiezingen.

How and to what extent the historic house (re-)constructs identity through image-making in China.

Kunst en vrije tijd, Kunst en vrije tijd

Het moet vanzelfsprekend worden om te investeren in kunst en cultuur. Dat stelde staatssecretaris Gunay Uslu vrijdagavond in de Huizingalezing. ‘Laten we volmondig erkennen dat we cultuur nodig hebben.’

In een paar jaar tijd is het beleid van de Chinese regering ten opzichte van de Oeigoeren sterk verslechterd. Van controle en marginalisering ging het naar een schending van mensenrechten. Promovenda Elke Spiessens zat er met haar onderzoek middenin. ‘De vezels van de gemeenschap worden volledig weg…

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

AI Labs zijn samenwerkingen van de Universiteit Leiden met externe partner zoals bedrijven, overheidsinstellingen en andere universiteit op het gebied van kunstmatige intelligentie. De Faculteit voor Wis-en Natuurkunde is uniek gesitueerd op het grootste Bioscience Park van Nederlands, en ligt direct…

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Promotor: G.R. de Snoo

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

This dissertation explores how Large Language Models (LLMs) can effectively and responsibly contribute to complex decision-making processes. By combining AI and human intelligence, Hybrid Intelligence (HI) emerges, allowing the strengths of both humans and machines to be utilized.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

The applications of studying the early development of insects range from agriculture to material science.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.