Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.

Promotor: M.A.G.J. Orrit

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Populistische oppositiepartijen houden zich niet zoveel bezig met het opstellen van beleid en wetgeving; zij zijn eerder gericht op het volgen en bekritiseren van de regering.

Hoe reageren de Afrikaanse landen Mali, Nigeria en Mozambique op gewapende jihadistische groeperingen in Afrika? Zien we verschillende patronen in repressie door de staat, weerstand van de gemeenschap en, in samenhang daarmee, de veiligheidssituatie in deze landen?

De onderzoeksgroep Cyber Security Governance bestudeert de impact van moderne technologie op governance, soevereiniteit, wetshandhaving en internationale betrekkingen, en levert toonaangevend academisch onderzoek en beleidsinzichten.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Bij kanker groeien lichaamscellen ongecontroleerd. Het gedetailleerd in kaart brengen van hoe dit precies gebeurt maakt het mogelijk om efficiënte therapieën te ontwikkelen. Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken samen aan het vermeerderen van…

Nederlandse kamerleden worden vooral gemotiveerd door hun directe werkomgeving: de parlementaire en partij-instituties en de daar geldende normen.

Promotieonderzoek is veeleisend en belonend. Of het nu gaat om een stap in je academische carrière of om de laatste fase in je universitaire opleiding, promotieonderzoek vereist denkkracht, creativiteit en doorzettingsvermogen. Het Instituut Politieke Wetenschap biedt je een professionele en ondersteunende…

De psychologen Fenna Poletiek en Erik de Kwaadsteniet krijgen van vakbond FNV een subsidie om te onderzoeken hoe mensen zich gaan gedragen ten opzichte van werk als ze een basisinkomen krijgen. Hoe gaan ze op zoek naar een antwoord?

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Promotores: J. Jonkers, K.E. de Visser

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

De LUMC Alumni Vereniging is in 1996 opgericht om enerzijds de band tussen het Leids Universitair Medisch Centrum en zijn alumni te versterken, anderzijds om de band van de alumni onderling te versterken.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

Promotor: Prof.dr. M. Ubbink

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Het identificeren van veranderingen in de hersenen die verband houden met suïcidale gedachten en gedragingen (STB's) bij jongeren is van cruciaal belang om de ontwikkeling ervan te begrijpen en vroegtijdige interventie en preventie te verbeteren.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Promotie

Promotie