In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

Sonja Boas ontwikkelde nieuwe technieken om het groeiproces van bloedvaten op computationele wijze te bestuderen. De resultaten van haar onderzoek geven een beter begrip van mechanismen in bloedvatgroei en dat is relevant voor de ontwikkeling van medische therapieën. Promotie op dinsdag 22 december…

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC), Chemical Biology & Immunology

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Valetudo, zo hebben de astronomen het nieuw ontdekte Jupitermaantje genoemd. Het is een weerbarstig exemplaar dat dwars tegen haar soortgenoten in beweegt. In de Volkskrant reageert Leidse astronoom Simon Portegies Zwart op de bijzondere ontdekking.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…

Het kanaal waarmee twee celonderdelen materiaal uitwisselen, blijkt zich aan de rand van hun contactoppervlak te vormen, en niet in het midden. Dat ontdekten de Leidse fysische scheikundigen Jelger Risselada en Edgar Blokhuis samen met onderzoekers van de Universiteit van Lausanne in Zwitserland. Ze…

Wetenschappers van de Universiteit Leiden hebben een doorbraak bereikt in de bestudering van de erfelijke stofwisselingsziekte van Pompe. Samen met hun Yorkse collega’s ontwierpen zij een molecuul dat zich bindt aan het enzym dat aan de basis staat van het ziekteverloop. De bevindingen zijn gepubliceerd…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Studievoorlichting

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

In de masteropleiding Linguistics (specialisation) van de Universiteit Leiden kun je kiezen uit acht thema's: Applied Linguistics; Comparative Indo-European Linguistics; Computational Linguistics; Language and Communication; Language Description and Documentation; Language Processing and Cognition;…

Altijd al een grafheuvel willen ontdekken? Of zelf willen speuren naar archeologische resten op de Veluwe? Doe dan nu mee met Erfgoed Gezocht! De Veluwe bevat zo veel archeologische resten dat archeologen alleen deze onmogelijk allemaal in kaart kunnen brengen! Je kan nu meedoen met de speurtocht via…

Video games have emerged as one of the most interesting media of the turn of the century. The peculiar characteristic of video games is the biunivocal interaction between the computer and the human player.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

De eer was aan Professor Simon Portegies Zwart en doctor Jeroen Bédorf om voor het blad IEEE Software te schrijven.

The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.