Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

This problem analysis raises the importance of a two interlinked questions: (1) what are important digital skills in the public sector? and (2) how well do different organizational and individual factors explain differences in skills levels?

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Promotie

Dit artikel biedt een systematisch literatuuronderzoek van de belangrijkste principes, normen en strategieën van Security by Design en Privacy by Design.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.

Including modelling as part of software development appears to have various benefits.

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: Prof.dr. L.J. Slikkerveer

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

De opzet van de Britse en Nederlandse missies in Zuid-Afghanistan werd ingegeven door Westerse vooringenomenheid, in plaats van door een gedegen, open analyse. Tot deze slotsom komt politicologe en majoor Mirjam Grandia in haar promotieonderzoek naar de Britse en Nederlandse besluitvorming rond de missies…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Onderzoeksvragen stellen en beantwoorden via samenwerking en open science.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Studievoorlichting

Promotor: S.M. Verduyn Lunel

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

In deze studie wordt verslag gedaan van een onderzoek naar de ontwikkeling van de praktijkkennis bij elf docenten Nederlands. Zij ontwikkelden en implementeerden concept-contextrijk onderwijs met behulp van actieonderzoek.

Op 26 juni 2019 verdedigde Lisa Louwerse haar proefschrift 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. Het promotieonderzoek is begeleid door promotor prof. mr. C.A.P. Hillion.

Promotor: Prof.dr. R.M.H. Merks

Een interdisciplinair team van Leidse wetenschappers heeft ontdekt dat de tering, een heftig bijverschijnsel van tuberculose, voor alle onderzochte mensen en diersoorten hetzelfde is. De ontdekking biedt nieuwe mogelijkheden om de nog onvoldoende begrepen aandoening te onderzoeken. De wetenschappers…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Yisheng Development gaat het nieuwe entreegebied van het Leiden Bio Science Park vorm geven. De Universiteit Leiden en de gemeente Leiden hebben gekozen voor de Amstelveense projectontwikkelaar, die een duurzaam ontwerp voor een levendige campus voorstelde. Het ontwerp combineert wonen, werken en le…

De Universiteit Leiden gaat een strategische samenwerking aan met de regionale ontwikkelingsbank Asian Development Bank. Voorzitter van het College van Bestuur Annetje Ottow ondertekende op 27 april in Manilla de intentieverklaring voor deze unieke samenwerking.

De Universiteit Leiden gaat verdere activiteiten met de Asian Development Bank (ADB) opzetten.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: Prof.dr. M.K. Richardson