Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotie

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: Prof.dr. B.R. Katzy

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Studievoorlichting

Kunsthistorica Sanne Frequin is geïntroduceerd als “friend of the show” bij het wetenschapsprogramma Focus in de Nacht op NPO Radio 1. Hier zal ze regelmatig aansluiten om te spreken over haar onderzoek en ontwikkelingen in haar vakgebied. In deze uitzending vertelt Frequin onder andere over haar fascinatie…

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Op 29 Juni 2017 heeft Doris Dull-Zessner haar proefschrift “Value Congruence in a Multinational Corporation” verdedigd. De supervisors zijn prof.dr.mr. J.A.A. Adriaanse and prof.dr. J.I. van der Rest.

Veel docenten in het voortgezet onderwijs houden rekening met verschillen tussen leerlingen. Uit het promotieonderzoek van Saskia Stollman (ICLON) blijkt dat zij hierbij ruimte om te experimenteren en ondersteuning van de school(leiding) nodig hebben.

Wout Broekema benadrukt dat organisaties niet alleen leren van crises, maar ook vergeten, waarbij cruciale kennis en werkwijzen verloren gaan.

This dissertation presents four separate chapters, all striving towards the same goal: to understand dynamic phenomena occurring in dynamic networks and to explore the emergence of equilibrium in a broad sense.

Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.

Deze praktische gids informeert studenten over de taal en andere vaardigheden die nodig zijn om een presentatie in het Engels te geven. Deze bondige en toegankelijke gids is bijzonder behulpzaam voor leerders van het Engels.

Investigating the intercultural connections that shaped practices of knowledge production in colonial Dutch Brazil.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Céline Zaepffel is docent aan het Leiden University Centre for the Arts in Society.

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Promotor: Prof.dr. G.R. de Snoo

Waar komt de Dag van de Arbeid vandaan? Hoogleraar Leo Lucassen geeft in het NPO Radio 1-programma ‘De Nacht van KRO-NCRV’ antwoord op die vraag.

The first biennial symposium Environmental History in the Medieval and Early Modern Low Countries is scheduled for October 25 and 26, 2024. This event aims to facilitate the exchange of recent research, ongoing projects, and key discussions within the realm of environmental history among scholars from…

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Promotie

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

The origin and evolution of galaxies are closely linked to many different physical phenomena.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.