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1,140 zoekresultaten voor “bart cancer” in de Publieke website

• Exploring Grainyhead-like 2 target genes in breast cancer Onderzoeksoutput

  The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

• RNA splicing in breast cancer progression Onderzoeksoutput

  In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

• Novel regulators of prostate cancer stem cells and tumor aggressiveness Onderzoeksoutput

  Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

• Identification of novel targets in prostate cancer progression Onderzoeksoutput

  Promotor: B. van de Water, Co-promotor: E.H.J. Danen

• Discovery of BUB1 kinase inhibitors for the treatment of cancer Onderzoeksoutput

  The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

• BRCA1-associated breast cancer: finding new weapons for an old villain Onderzoeksoutput

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• multifaceted roles of Grainyhead-like transcription factor-2 in breast cancer Onderzoeksoutput

  Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

• Cancer chess: molecular insights into PARP inhibitor resistance Onderzoeksoutput

  The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

• Patient-derived models of breast cancer: a breakthrough story of the duct Onderzoeksoutput

  To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

• PI3K signaling and adherens junctions in invasive lobular breast cancer Onderzoeksoutput

  Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

• Pulling the strings on anti-cancer immunity Onderzoeksoutput

  Promotores: J. Jonkers, K.E. de Visser

• Blueprints of Disease: Precision Platforms for Modelling Breast Cancer Onderzoeksoutput

  Breast cancer (BC) is a clinically and biologically heterogeneous disease.

• Modeling and Targeting Tissue Dynamics in Fibrosis and Cancer Onderzoeksoutput

  Drug development is hampered by the limited predictive value of conventional 2D culture systems, which fail to recapitulate the complexity of the disease microenvironment and contribute to high clinical attrition rates.

• Precision modeling of breast cancer in the CRISPR era Onderzoeksoutput

  The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

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  Bart Stastny onderwijs onderzoek medewerker

  Faculteit der Geesteswetenschappen

  b.stastny@hum.leidenuniv.nl |

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  Bart Mertens

  b.j.a.mertens@lumc.nl | 31641355368

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  Bart Gorissen Docent

  Faculteit Rechtsgeleerdheid

  b.j.e.gorissen@law.leidenuniv.nl | 071 5272727

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  Bart Hoenen Advisor Entrepreneurship (gast)

  LURIS

  b.m.j.hoenen@leh.leidenuniv.nl | 071 5272531

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  Bart Bulsing Technisch Informatiebeheerder / Tekenaar

  Expertisecentrum Vastgoed

  b.m.bulsing@vastgoed.leidenuniv.nl | 071 5271203

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  Bart Wentholt Meewerkend coördinator MDA open access

  Universitaire Bibliotheken Leiden

  b.l.r.wentholt@library.leidenuniv.nl | 071 5272727

• genes driving tumorigenesis and therapy resistance in human breast cancer Onderzoeksoutput

  To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

• Bart Barendregt Dossier: Leiden Teachers’ Academy

  Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

• Bart Barendregt Dossier: Leiden Teachers’ Academy

  Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

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  Bart Alewijnse Programmeur/lab technicus

  Faculteit der Geesteswetenschappen

  b.alewijnse@hum.leidenuniv.nl | 071 5272320

• Image-based phenotypic screening for breast cancer metastasis drug target discovery Onderzoeksoutput

  The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

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  Bart Gorissen Docent

  Faculteit der Rechtsgeleerdheid

  b.j.e.gorissen.2@law.leidenuniv.nl |

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  Bart Zantvoort Docent

  Faculteit der Geesteswetenschappen

  f.w.zantvoort@phil.leidenuniv.nl | 071 5272727

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  Bart Roep Hoogleraar

  b.o.roep@lumc.nl | 071 5263869

• Liposome-based synthetic long peptide vaccines for cancer immunotherapy Onderzoeksoutput

  Promotores: Wim Jiskoot; Ferry Ossendorp

• Development of novel anti-cancer strategies utilizing the zebrafish xenograft model Onderzoeksoutput

  In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

• The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis Onderzoeksoutput

  In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

• Disrupting the transcriptional machinery to combat triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

• Acquired resistance in pancreatic cancer: characterization and exploration of actionable targets of a multifactorial disease Onderzoeksoutput

  Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

• Uncovering vulnerabilities in triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

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  Bart Wielders Promovendus / buiten

  Faculteit Governance and Global Affairs

  b.wielders@fgga.leidenuniv.nl | 070 8009500

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  Bart Lenselink Gast Onderzoeker

  e.b.lenselink@lacdr.leidenuniv.nl | 071 5272727

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  Bart van Hoek Emeritus hoogleraar

  b.van_hoek@lumc.nl | 071 5269111

• Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model Onderzoeksoutput

  Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

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  Bart Vogelaar Universitair docent

  Faculteit der Sociale Wetenschappen

  b.vogelaar.2@fsw.leidenuniv.nl | 071 5276022

• Targeted Therapy for Triple-Negative Breast Cancer Onderzoeksoutput

  The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

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  Bart Collard Buitenpromovendus

  Faculteit der Rechtsgeleerdheid

  b.j.collard@law.leidenuniv.nl | 071 5275200

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  Bart Schreuders Onderzoeker/docent

  Faculteit der Rechtsgeleerdheid

  h.g.schreuders@law.leidenuniv.nl | 071 5272727

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  Bart de Vries Gast

  Faculteit der Sociale Wetenschappen

  h.e.j.de.vries@fsw.leidenuniv.nl | 071 5272727

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  Bart van der Hoogt Stagiair

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  Bart Verheijen Universitair docent

  Faculteit der Geesteswetenschappen

  l.j.verheijen@hum.leidenuniv.nl | 071 5271743

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  Bart Joosen Gastdocent

  Faculteit der Rechtsgeleerdheid

  e.p.m.joosen@law.leidenuniv.nl | 071 5272727

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  Bart Verkuil Universitair Hoofddocent

  Faculteit der Sociale Wetenschappen

  bverkuil@fsw.leidenuniv.nl | 071 5273460

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  Bart Barendregt Decaan/hoogleraar

  Faculteit der Sociale Wetenschappen

  barendregt@fsw.leidenuniv.nl | 071 5273475

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  Bart Schermer Hoogleraar

  Faculteit der Rechtsgeleerdheid

  b.w.schermer@law.leidenuniv.nl | 071 5278838

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  Bart Krans Hoogleraar Burgerlijk recht en Burgerlijk procesrecht

  Faculteit der Rechtsgeleerdheid

  h.b.krans@law.leidenuniv.nl | 071 5274783