The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotores:Th.J.C. van Berkel, M. van Eck

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Promotor: Prof.dr. H.L.V. Linnartz

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Cardiovascular diseases are still a major concern for the global health.

Lezing, European Union Seminar

Op vrijdag 2 december 2016 heeft een internationale onderzoeksconferentie plaatsgevonden in Leiden. Deze was georganiseerd door de onderzoeksgroep van Coherent Privaatrecht. De conferentie droeg de titel “Private law and market regulation – interaction, interference or inconsistency?”. Het centrale…

De universiteit streeft ernaar dat alle studenten in hun opleiding kennismaken met duurzaamheidsthema’s en -vraagstukken, die zoveel mogelijk aansluiten bij de inhoud van hun opleiding.

Op vrijdag 23 november organiseert het Instituut voor Immigratierecht en de afdeling Jeugdrecht (beiden Universiteit Leiden) een internationaal congres met de titel 'Safeguarding children’s rights in immigration law'.

For the first time Leiden Law School students have the opportunity to take part in the Ian Fletcher International Insolvency Law Moot. It involves students from around the world and deals with international insolvency law litigation. With a support team of academics and practitioners experienced in…

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

As Leiden Law students, we are now in the digital age, 'where we believe law and technology should go together.' After all, for us, it is important to look beyond trodden paths of established legal knowledge. The books on law and case law surely will not be sufficient for the lawyer of the future. That…

Medewerkers en studenten van onze faculteit laten vanuit hun eigen expertise hun licht schijnen op de coronacrisis. Hun bijdragen zijn gebundeld te vinden op het Leiden Law Blog in het dossier 'Law & Corona'.

Suliman Ibrahim werd geïnterviewd in het Leids Universitair Weekblad ‘Mare’ over zijn onderzoek in Libië.

In april gaat de Honours Class ‘Law, Power, and Inequality: Global Perspectives’ van Hoogleraar Rechtssociologie Maartje van der Woude van start. Een unieke Class met veel innovatie, zowel qua inhoud en samenwerking als de vormgeving.

Classicus Renske Janssen ontvangt een Rubiconbeurs. Ze gaat hiermee aan de Universiteit van Edinburgh onderzoek doen naar de beleving van het Romeins recht in de toenmalige samenleving.

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Op 7 november 2018 verdedigde Catherine Harwood haar proefschrift 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. Het promotieonderzoek is begeleid door promotoren prof. dr. L.J. Van den…

Op 12 en 13 september 2019 ontving het Instituut voor Fiscale en Economische vakken 29 promovendi van over de hele wereld voor een congres over internationaal belastingrecht.

Dr. Robert Heinsch en zijn team van IHL Clinic-onderzoekers van het Kalshoven-Gieskes Forum on International Humanitarian Law hebben een prestigieuze Erasmus+-beurs gewonnen voor samenwerkingsprojecten met de Ruhr-Universität Bochum (Duitsland) en de Roma Tre-universiteit (Italië).

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Curved single crystals provide variable, but well-defined surface structures.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.