750 zoekresultaten voor “cell mobility” in de Publieke website
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Gevolgen van pesticiden in natuur volop in het nieuws
Veel media besteden aandacht aan de gevolgen van pesticiden in de natuur. Onder andere in Trouw vertelt hoogleraar Martina Vijver dat niet alleen pesticiden die boeren gebruiken, maar ook schoonmaakmiddelen en muggenspray een groot effect op leven in het water. 'Als schadelijke stoffen in het water…
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Erik Danen wil tumoren vangen in hun eigen web
Erik Danen speurt met succes naar wegen om tumoren die slecht op medicijnen reageren de pas af te snijden. De hoogleraar Cancer Drug Target Discovery kijkt hiervoor naar de interactie tussen tumorcellen en hun omgeving. Oratie vrijdag 10 mei.
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Cecile HerbermannWiskunde en Natuurwetenschappen
c.j.herbermann@lacdr.leidenuniv.nl | 071 5272727
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Micha DrukkerWiskunde en Natuurwetenschappen
m.drukker@lacdr.leidenuniv.nl | +31 71 527 6271
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Nina SchultenWiskunde en Natuurwetenschappen
n.schulten@lacdr.leidenuniv.nl | 071 5272727
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Ferdinand TeichertWiskunde en Natuurwetenschappen
f.m.a.teichert@lacdr.leidenuniv.nl | 071 5272727
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Benjamin TakWiskunde en Natuurwetenschappen
b.l.t.tak@lacdr.leidenuniv.nl | +31 71 527 6228
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Max FernkornWiskunde en Natuurwetenschappen
m.fernkorn@lacdr.leidenuniv.nl | +31 71 527 2727
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Rafaella BuzatuWiskunde en Natuurwetenschappen
r.buzatu@lacdr.leidenuniv.nl | +31 71 527 6227
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Yuting WangWiskunde en Natuurwetenschappen
y.wang@lacdr.leidenuniv.nl | 071 5272727
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Perspectives on decision making in hematopoietic stem cell transplantation
Promotie
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Targeting tumors using T-cell receptor gene transfer
Promotie
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T-cell gene therapy for low mutational burden cancer
Promotie
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Deciphering myeloid (progenitor) cell function and communication in (tumor) tissues
Promotie
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Amoeboid cell migration and physicochemical properties of the extracellular environment
Promotie
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Single-cell mechanics for disease biology and pharmacology
Promotie
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Improving care for red blood cell alloimmunized pregnant women
Promotie
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Rafaël VosWiskunde en Natuurwetenschappen
r.e.vos@lic.leidenuniv.nl | 071 5272727
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Bart Kramer
Wiskunde en Natuurwetenschappen
b.kramer@lacdr.leidenuniv.nl | +31 71 527 4220
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Piecewise deterministic Markov processes: an analytic approach
Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Wiskunde en Natuurwetenschappen
Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen omvat de disciplines wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde, bio-farmaceutische wetenschappen, biologie en milieuwetenschappen.
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Microglial lipid metabolism: a delicate balance
Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.
- Agenda
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Call for Papers - Hagio-Scape Conference (Rome)
This conference investigates the specific role of mobility and materiality in the creation of (trans)regional sacred landscapes and cityscapes, taking a longue durée perspective. In particular, our aim is to address the role of mobility of objects, texts, and persons in the creation of sacred topographies.…
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Duurzaamheid in onderwijs
De universiteit streeft ernaar dat alle studenten in hun opleiding kennismaken met duurzaamheidsthema’s en -vraagstukken, die zoveel mogelijk aansluiten bij de inhoud van hun opleiding.
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Call for papers: Who is Asian? Definitions, Representations, and Marginalizations
Congres/symposium, Call for papers
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Over het programma
In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.