587 zoekresultaten voor “cell mobility” in de Publieke website
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Max FernkornWiskunde en Natuurwetenschappen
m.fernkorn@lacdr.leidenuniv.nl | +31 71 527 2727
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Rafaella BuzatuWiskunde en Natuurwetenschappen
r.buzatu@lacdr.leidenuniv.nl | +31 71 527 6227
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Yuting WangWiskunde en Natuurwetenschappen
y.wang@lacdr.leidenuniv.nl | 071 5272727
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Rafaël VosWiskunde en Natuurwetenschappen
r.e.vos@lic.leidenuniv.nl | 071 5272727
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Bart Kramer
Wiskunde en Natuurwetenschappen
b.kramer@lacdr.leidenuniv.nl | +31 71 527 4220
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Microglial lipid metabolism: a delicate balance
Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Piecewise deterministic Markov processes: an analytic approach
Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Over het programma
In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.
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Call for Papers - Hagio-Scape Conference (Rome)
This conference investigates the specific role of mobility and materiality in the creation of (trans)regional sacred landscapes and cityscapes, taking a longue durée perspective. In particular, our aim is to address the role of mobility of objects, texts, and persons in the creation of sacred topographies.…
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Duurzaamheid in onderwijs
De universiteit streeft ernaar dat alle studenten in hun opleiding kennismaken met duurzaamheidsthema’s en -vraagstukken, die zoveel mogelijk aansluiten bij de inhoud van hun opleiding.
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Universiteit Leiden verdubbelt Europese subsidie voor uitwisseling
Bijna honderd studenten en wetenschappers kunnen op uitwisseling van en naar de Universiteit Leiden. Veertien uitwisselingsprojecten kregen een subsidie toegekend uit het Erasmus+ International Credit Mobility-programma van de Europese Unie.
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Leiden versterkt band met Latijns-Amerika en Cariben
Ambassadeurs uit elf Latijns-Amerikaanse en Caribische landen maakten op 15 mei kennis met de paradepaardjes van het onderzoek van de Leidse bètafaculteit. Prins Carlos de Bourbon de Parme reikte prijzen uit aan twee jonge wetenschappers die onderzoek doen in Latijns-Amerika.
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The T cell-myeloid axis in the success and failure of cancer immunotherapy
Promotie
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unchained; molecular mechanisms of ubiquitin-like signal transduction in cell cycle progression
Promotie
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cardiac safety and drug discovery screening using human stem cell-derived cardiomyocytes
Promotie
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therapies for mitochondrial cardiomyopathies using advanced human stem cell models
Promotie
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Burden of disease and quality of life in patients with cutaneous T-cell lymphoma
Promotie
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On the origin and evolution of the autoreactive B cell response in rheumatoid arthritis
Promotie
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Quest for the cure: Towards Improving Hematopoietic stem cell based lentiviral gene therapy
Promotie
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Biomarkers for the response to immunotherapy in patients with non- small cell lung cancer
Promotie
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Molecular approaches to identify cancer T cell antigens and improve immunogenicity
Promotie
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Inflammatory and metabolic features of stromal cell subtypes in inflammatory bowel disease
Promotie
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Immune-evasive iPSCs as universal cell source for kidney regeneration in transplantation therapy
Promotie
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Primary and secondary resistance mechanisms in EGFR mutated non- small cell lung cancer
Promotie
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Crossing borders - on the treatment of stage III melanoma and Merkel cell carcinoma
Promotie
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Understanding and Targeting Coronaviruses Exploring advanced cell culture models and host-directed antiviral strategies
Promotie
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Modeling vascular inflammation with immune cell-vessel crosstalk in hiPSC-derived 3D vessels-on-chip
Promotie
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In Vitro Recapitulation of Female Germ Cell Development: From Specification to Meiosis Initiation
Promotie
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Keeping Up the Pace: Developing Gene and Cell-Based Biological Pacemakers
Promotie