Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Promotor: Prof.dr. S. Haring

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Cardiovascular disease is the leading cause of death worldwide.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

MCS, en het onderzoek dat door ons gedaan wordt, heeft sterke banden met de twee Leidse masterspecialisaties op het gebied van museum studies; bij de opleiding Kunstgeschiedenis en bij Archeologie.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Lees meer over voorlichtingsactiviteiten voor de MSc International Organisation aan Universiteit Leiden, zoals webinars, virtuele sessies en Q&A’s over de aanmelding.

Met het afronden van je bachelor zet je een belangrijke stap. Maar daarmee is je academische vorming nog niet helemaal ‘af’. Veel opleidingen en banen vragen om meer. Daarom stimuleert de Universiteit Leiden je om na je bacheloropleiding door te gaan met de masteropleiding. Jouw Leidse bachelordiploma…

Ontdek de voorlichtingsactiviteiten rond de MSc Democracy and Representation aan Universiteit Leiden: online open dagen, Q&A-sessies en virtuele rondleidingen.

Lees meer over de MSc International Politics aan Universiteit Leiden: programma-opbouw, kernvakken, thesis-seminar en kleinschalige begeleiding in Den Haag.

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Het VVI heeft als doel bij te dragen aan de sociaal-wetenschappelijke kennisvorming over de interactie tussen recht, bestuur en samenleving. Het VVI-onderzoek richt zich in het bijzonder op het ontstaan en functioneren van juridische instituties. Daarbij kijken de onderzoekers zowel naar de perspectieven…

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Lees meer over informatiebijeenkomsten en activiteiten voor de masteropleiding The Politics of Artificial Intelligence aan de Universiteit Leiden, waaronder webinars, virtuele sessies en vragen en antwoorden over de aanmeldingsprocedure.

Lees meer over informatieve activiteiten voor de MSc International Politics aan Universiteit Leiden, zoals webinars, online Q&A-sessies en evenementen voor toekomstige studenten.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: A.P. IJzerman

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

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Het hoofd van MCS is tevens directeur van het LDE Centre for Global Heritage and Development, in Leiden gevestigd, voorzitter van LeidenGlobal en staflid van de Heritage and Museums afdeling bij de faculteit archeologie. Er worden gezamenlijk activiteiten ontplooid die op het grensvlak liggen van erfgoed…

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.