Promotie

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Promotor: K.H. Kuijken

Promotor: J.M. Memelink

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Migratie en criminaliteit staan maatschappelijk volop in de schijnwerpers. Binnen het instituut voor Strafrecht en Criminologie heeft onderzoek op dit terrein zich de laatste jaren sterk ontwikkeld. Het begrip Crimmigratie staat daarbij centraal.

De leerstoel Democratische Vertegenwoordiging in het Koninkrijk richt zich op de politieke relaties tussen Europees Nederland en de zes Caribische eilanden in het Koninkrijk; de zogenaamde Koninkrijksrelaties. In het kader van de leerstoel doet Prof. dr. Wouter Veenendaal onderzoek naar de kwaliteit…

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In november 2020 is het Engelstalige boek ‘Financial Collateral; Law and Practice’ verschenen. Het boek is gepubliceerd door Oxford University Press en geredigeerd en geschreven door professor Matthias Haentjens. Voorts hebben meegeschreven Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

Promotor: G.P. van Wezel

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: B. van de Water

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotores: G. Persoon, R. Schefold

Promotor: J. Aarts

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Promotores: Wim Jiskoot; Ferry Ossendorp

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Control of infectious diseases poses continuous challenges for human health.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Promotor: Prof.dr. D. Bouwmeester

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: Roeland M.H. Merks

Gendergerelateerd geweld is een urgent maatschappelijk probleem dat jaarlijkse vele levens ingrijpend raakt. De ernst en complexiteit ervan vragen om een doordachte en professionele aanpak, met oog voor slachtoffers, daders, de context en het systeem