Farmacoloog Walter Boiten ontwikkelde een nieuwe methode om de hoeveelheid vetten in iemands huid te kunnen bepalen. Met de methode testte hij de effecten van een nieuwe crème die hij ontwikkelde voor eczeempatiënten. De eerste resultaten zijn veelbelovend. Boiten promoveert op 15 januari.

Dit was het programma van De Kennisboomgaard 2025:

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: A. Kros

This thesis focuses on the study of transient and variable radio sources in the universe.

Promotor: M.A.G.J. Orrit

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Overzicht

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

In this work, we attempt to answer the question:

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Consequences for sediment stability and seston trapping

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Promotores: J.N. Kok, H.J. Hoogeboom

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotores: T.H. Oosterkamp, N. de Jonge

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Het is tijd dat de internationale gemeenschap een halt toeroept aan oorlogsmisdaden - in het bijzonder tegen medisch personeel. Dat zei internationaal voorzitter Joanne Liu van Artsen zonder Grenzen tijdens de Cleveringa-oratie.

Op donderdag 24 november gaf Joanne Liu een extra lezing over ebola in het Leids Universitair Medisch Centrum (LUMC). Dat deed zij voorafgaand aan haar Cleveringa-oratie op 25 november.

Promotie

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Cardiovascular diseases are still a major concern for the global health.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

Promotor: Prof.dr. M. Schilthuizen

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

De sectie Cognitieve Psychologie is als volgt georganiseerd:

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Cardiovascular syndromes are the major cause of death in Western societies.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

This thesis describes the design, characterization and application of dextran based crosslinked network.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…