This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

Promotores: G. Persoon, R. Schefold

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: G.P. van Wezel

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: J. Aarts

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Gendergerelateerd geweld is een urgent maatschappelijk probleem dat jaarlijks het leven van vele mensen in Nederland ingrijpend raakt. De ernst en complexiteit ervan vragen om een doordachte en professionele aanpak, met oog voor slachtoffers, daders, de context en het systeem.

Promotie

Promotie

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotores: W. Jiskoot, F. Ossendorp

Promotor: Prof.dr. D. Bouwmeester

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Naast het feit dat angstproblemen veelvoorkomend zijn en het daarom belangrijk is om hier effectieve preventieve programma’s en behandelingen voor te ontwikkelen, is dat in deze tijd extra relevant.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

In november 2020 is het Engelstalige boek ‘Financial Collateral; Law and Practice’ verschenen. Het boek is gepubliceerd door Oxford University Press en geredigeerd en geschreven door professor Matthias Haentjens. Voorts hebben meegeschreven Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

In this thesis integral points on affine del Pezzo surfaces are studied.

Promotor: B. van de Water

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Leiden en Den Haag hebben veel musea met grote aantallen bijzondere voorwerpen en archieven. Ook de Universiteit Leiden herbergt bijzondere collecties. Museums, Collections & Society bevordert onderzoek en onderwijs en stelt ethische vragen omtrent de herkomst van deze collecties.

Op 9 juni 2021 verdedigde Bahaddin Budak succesvol zijn proefschrift en promoveerde.

Met dit project wordt van een evidence-based onderwijsmethodiek (toolkit) ontwikkeld voor docenten van alle vakgebieden in het hoger onderwijs voor het effectief omgaan met controversiële onderwerpen in de les.

Leidse expertise over het Midden-Oosten strekt van de eeuwenoude geschiedenis tot hedendaagse spanningen in de regio. Door talen, culturen, religies, literatuur, kunst en filosofie in samenhang met elkaar te bestuderen, creëren we onmisbaar diepgaand begrip.

​​​​​​​Wereldwijd krijgen jaarlijks ongeveer 9 miljoen mensen tuberculose. Onderzoek naar nieuwe medicijnen tegen deze ziekte heeft een flinke impuls gekregen door efficiëntere technieken en nieuwe inzichten in hoe de tuberculosebacterie werkt.