Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Een van de heilige gralen in het geneesmiddelonderzoek is de veiligheid van chemische stoffen en farmaceutische producten te kunnen beoordelen zonder gebruik van proefdieren. Onderzoekers van onder meer de Universiteit Leiden krijgen daarvoor nu een subsidie van de Nationale Wetenschapsagenda.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Dissociative chemisorption is an important reaction step in many catalytic reactions.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Software development is a complex process. It is important that software products become stable and maintainable assets.

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

Promotor: G. J. Kroes

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

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Een internationale groep wetenschappers heeft ontdekt dat bepaalde cellen van ons immuunsysteem – de zogenaamde T-cellen – onderling communiceren en als een team samenwerken: om een infectie te bestrijden stimuleren ze elkaars groei, maar tegelijkertijd remmen ze elkaar af wanneer er een overschot aan…

Waddenzeegeluiden: zo heet het project dat de Waddenvereniging samen met onderzoekers van Universiteit Leiden en Rijksuniversiteit Groningen start. Doel is te achterhalen wat de invloed van geluid op het onderwaterleven in de Waddenzee is.

Het was lange tijd één van de meest bedreigde diersoorten ter wereld. Ruim tien jaar geleden dacht men zelfs nog dat hij was uitgestorven: de Filipijnse krokodil.

De zeldzame Ethiopische wolf komt steeds vaker in aanvaring met lokale veehouders. Promovendus Girma Eshete zocht naar manieren om het elegante beest te redden van de ondergang. Promotie op 5 september.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

De Microscopy Unit huisvest, onderhoudt en coördineert vrijwel alle microscopieapparatuur van het IBL. De beschikbare apparatuur varieert van conventionele licht- en fluorescentiemicroscopen tot confocale laser- en elektronenmicroscopen. Er is bovendien apparatuur beschikbaar voor histologie, met inbegrip…

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Dit project beoogt de ontwikkeling van geavanceerde data-analysemethoden voor monitoring en het vergroten van ons inzicht in de dynamiek van de biodiversiteit in natuurgebieden zoals de Oostvaardersplassen.

Promotor: Prof.dr. S. Haring

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: J.N. Kok, Co-promotor: M.S. Lew

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).