Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

The focus of the dissertation

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Waar vindt u ons?

Op deze pagina verzamelen we de presentaties en video's van de Florence Nightingale Colloquia, seminars bij de faculteiten en andere evenementen gehost door het Data Science Onderzoeksprogramma.

This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.

Security and safety challenges rank among the most pressing issues of modern times. Challenges such as cyber-crime, terrorism, and environmental disasters impact the lives of millions across the globe. The course will introduce you to this broad theme in an increasingly complex world.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

Stelt

In this course, we will focus on the fascinating history of the Arabic Medieval World. We will take you on a journey through the Middle Ages. All along, we will present you with historiographical debates and dilemmas and travel back and forth in time explaining to you how events of the past affected…

Studievoorlichting

Studievoorlichting

Ontdek de microcredential SDGs, Human Rights and International Law van de Faculteit Governance and Global Affairs en blijf een leven lang leren! Lees hier meer!

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Zelf met leerlingen aan de slag in een zoektocht naar antibiotica? Met het practicum Antibiotica Gezocht! gaan bovenbouw havo- en vwo-leerlingen tijdens de biologieles op zoek naar (nieuwe) antibioticum-producerende bacteriën.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

In this thesis,

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Promotor: M.A.G.J. Orrit

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: B. van de Water

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Onderzoek en onderwijs zijn twee belangrijke pijlers van het SAILS-programma. Een andere kernactiviteit is communicatie over ons onderzoek met wetenschappers, het bedrijfsleven en andere maatschappelijke partners.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Studievoorlichting

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Voorspellingen doen over emotionele problemen of de effecten van lichtvervuiling: algoritmen van Marjolein Fokkema kunnen het steeds beter. Ze maakt haar algoritmen steeds flexibeler, zodat ze niet alleen kenmerken op één moment kunnen voorspellen, maar ook hoe bijvoorbeeld vaardigheden toe- of afne…