If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Hoe zag de keizerlijke rechtsbedeling en gerechtelijke oordeelsvorming onder de Severische keizers eruit?

Het secretariaat (kamer 2B07) wordt bemenst door Eva Potters en Pauline Ruygrok

Promotie

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Publicaties Onderwijs- en organisatieontwikkeling

Dit onderzoeksprogramma brengt door het verkennen van de grenzen van het internationaal publiekrecht deze verandering van de internationale rechtsorde in kaart.

Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…

Wat is de institutionele dynamiek van de goedkeuring van wetgeving inzake de interne markt?

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

Onderzoek dat binnen het instituut wordt uitgevoerd valt onder het onderzoeksprogramma Criminal Justice: Legitimacy, Accountability and Effectivity. In dit onderzoeksprogramma werken (strafrecht)juristen en sociaal wetenschappers, in het bijzonder criminologen, nauw samen.

Groeiende gezondheidsverschillen, toenemende zorgkosten, de vergrijzing en het tekort aan zorgpersoneel zijn slechts enkele voorbeelden van uitdagingen waar de gezondheidszorg voor staat, zowel in Nederland als daarbuiten. Deze vraagstukken overstijgen de grenzen van de medische sector en raken aan…

Criminal Justice Onderzoeksprogramma van het Instituut voor Strafrecht en Criminologie

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

Promotie

Promotores: H. Schiessel, G.T. Barkema

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: A. Kros

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Supervisor: P.J.J. Hooykaas

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: T. Schmidt

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: Prof.dr. B. van de Water

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis