The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Wat doe je als je iets te weten wilt komen? Tegenwoordig gebruikt men voornamelijk het internet om informatie te verkrijgen. Een lezer moet deze informatie vaak uit meerdere bronnen halen en die bronnen met elkaar in verband brengen, om zo een compleet plaatje te vormen van het onderwerp. Soms is de…

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

De rol van de Raad van State staat opnieuw ter discussie. Kritiek uit de politiek botst met staatsrechtelijke analyses, terwijl experts waarschuwen voor aantasting van het gezag van het instituut. Staatsrechtgeleerde, Wim Voermans, duidt de zaak in een artikel van JAS nieuws.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Lezing

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Luc Verheij hoogleraar Staats en bestuursrecht (Kircheiner-leerstoel) in Leiden wordt lid van de Raad van State. Sinds 2011 is Verheij al staatsraad in de Afdeling advisering. Deze rol blijft hij vervullen en wordt daarnaast ook lid van deze Raad.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

This dissertation presents new cryptographic protocols, which can be divided into two families.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

In dit artikel onderzoeken Thijs van Dooremalen en Philip Smith hoe het publieke discours over hittegolven is verschoven in Britse kranten.

Lezing

Promotie

Op 28 februari 2019 verdedigde Kabir Duggal zijn proefschrift 'Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences'. Het promotieonderzoek is begeleid door promotor prof. dr. E. De Brabandere.

In dit artikel onderzochten Martin Sievert en Jonas Bruder of en hoe administratieve lasten van invloed zijn op de perceptie van burgers van het welzijnsbeleid en hun houding tegenover uitkeringsgerechtigden.

Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.