Promotor: Prof.dr. B.R. Katzy

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Elektrische signalen bewegen als een golf door onze zenuwbanen. De wiskundige modellen voor deze bewegingen konden nog niet alle biologische eigenschappen van de zenuwbanen goed beschrijven. Promovendus Willem Schouten-Straatman bracht hier verandering in door de bestaande modellen te verbeteren. 'Ik…

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

Promotor: Prof. dr. A.G.G.M. Tielens

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…

Promotor: Prof.dr. M.K. Richardson

Dr. Irma Mosquera Valderrama onderzoekt in haar ERC-project de rol van de OESO (Organisatie voor Economische Samenwerking en Ontwikkeling) en de EU bij de totstandkoming van internationale fiscale wetgeving en streeft ernaar voorwaarden te scheppen waaronder zowel ontwikkelde landen als ontwikkelingslanden…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

De Vereniging van Nederlandse Gemeenten heeft in samenwerking met het Ministerie van Binnenlandse Zaken en Koninkrijksrelaties een klankbordgroep in het leven geroepen die moet adviseren over eventuele wijzigingen van de VNG model referendumverordening. Joost Westerweel neemt daarin plaats om vanuit…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

Promotores: H. Schiessel, G.T. Barkema

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotie

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Elke dag nemen we vele beslissingen; van wat we eten tot hoe we de wereld om ons heen interpreteren. Over het algemeen gingen onderzoekers ervan uit dat een belangrijk onderdeel van ons besluitvormingsproces, namelijk het beslissingscriterium, stabiel blijft. Er zijn echter steeds meer aanwijzingen…