Promotor: Prof.dr. G.R. de Snoo

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Wij voeren multidisciplinair onderzoek uit op het niveau van moleculen, cellen en organismen binnen de dierkunde. Ons doel is om fundamentele kennis te vergroten over gezondheid en ziekte.

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

De missie van het Plant Sciences onderzoeksprogramma is om bij te dragen aan de duurzame productie van gewassen van hoge kwaliteit, bloemen en hoogwaardige producten met een biologische basis. Dit wordt gerealiseerd door het opdoen van fundamentele kennis over biologische processen omtrent de ontwikkeling…

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

Celebrating 20 years of Environmental Research and Education in Northern Cameroon

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.

In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

In deze opleiding streef je naar het beantwoorden van biologische vraagstukken in relatie tot milieu, ecologie en andere maatschappelijk relevante onderwerpen.

In het onderzoeksprogramma Microbial Biotechnology voeren wij vernieuwend onderzoek uit in de biotechnologie en microbiologie.

Onder het Instituut voor Fiscale en Economische vakken van de Faculteit der Rechtsgeleerdheid vallen de afdelingen Belastingrecht, Economie en Bedrijfswetenschappen.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

De traditionele scheiding van leeuwen in een Afrikaanse en een Aziatische ondersoort is onterecht, zegt bioloog Laura Bertola. In Afrika leven twee ondersoorten. Promotie 18 maart.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Promotor: Prof.dr. H.S. Overkleeft

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Prof.dr. M. Ubbink

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

How can we bridge the gap between experts and the general public?

DNAmarkerpoint heeft als doel ecologie, evolutie en biodiversiteit beter te begrijpen door het bestuderen van modern en ancient DNA.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Projecten van de afdeling Environmental Biology

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal