Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Promotores: S.J. Edixhoven, F. Andreatta

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Promotor: P.D. Grünwald

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Promotores: J. Jonkers, K.E. de Visser

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Promotores: Wim Jiskoot; Ferry Ossendorp

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Het Anatomisch theater in Museum Boerhaave is op dinsdag 28 april het toneel van een tafereel dat al jaren niet meer is waargenomen. Dr. Frans Witte geeft er zijn college Ontwikkelingsbiologie aan de hand van de papier-maché modellen van de Franse arts Auzoux.

Promotor: Richard D. Gill

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

Promotor: S.M. Verduyn Lunel

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Overlevingsanalyse is een onderzoeksgebied dat zich richt op het bestuderen van de tijd tot het optreden van een specifieke uitkomst.

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The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Blijf op de hoogte van alle nieuws en activiteiten op het gebied van diversiteit en inclusie.

Vandaag de dag liggen statistische methodes aan de grondslag van beslissingen in allerlei facetten van het leven, van de gezondheidszorg en agricultuur tot de financiële sector en marketing.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov